Research ArticleThe State of the Art

First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*

Ramsey D. Badawi, Hongcheng Shi, Pengcheng Hu, Shuguang Chen, Tianyi Xu, Patricia M. Price, Yu Ding, Benjamin A. Spencer, Lorenzo Nardo, Weiping Liu, Jun Bao, Terry Jones, Hongdi Li and Simon R. Cherry
Journal of Nuclear Medicine March 2019, 60 (3) 299-303; DOI: https://doi.org/10.2967/jnumed.119.226498

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Photograph of completed EXPLORER total-body PET/CT scanner.

  • FIGURE 2.
    FIGURE 2.

    Selected views from total-body scan of subject 1. (A) Total-body MIP. (B) Total-body sagittal view. (C) Head/neck view, with arrow indicating walls of right carotid artery. (D) Chest view, showing walls of major blood vessels, with ascending aorta indicated by arrow. (E) Midthoracic view with spinal canal indicated by arrow. (F) Abdomen and pelvis, showing clear delineation of endplates of vertebral bodies (arrow points to superior endplate of L3). (G) Knees, with bone spur indicated by arrow. (H) Lower extremities, with arrow showing delineation of medial tibial malleolus.

  • FIGURE 3.
    FIGURE 3.

    Views from subject 1 as function of scan duration (290 MBq injected, 82 min uptake period). (Top) Sagittal views from 20 min to 18.75 s. (Bottom) Coronal views at 75, 37.5, and 18.75 s.

  • FIGURE 4.
    FIGURE 4.

    Delayed imaging for subject 2 (256 MBq injected, 14 min scan duration). (Left-to-right) Images from scans performed at 1, 3, 8, and 10 h after injection. (Top row) MIP images. (Bottom row) Coronal views of thorax and abdomen. Head motion artifacts are visible in 8-h scan.

  • FIGURE 5.
    FIGURE 5.

    Low-dose images from subject 4. Subject was injected with 25 MBq and scanned for 10 min after 52.5 min of uptake time. Total-body MIPs (left) and coronal view of upper body (right). Tracer was injected into a vein in right lower leg.

  • FIGURE 6.
    FIGURE 6.

    Dedicated brain scan from subject 3. Motion correction has not been implemented at this time.

  • FIGURE 7.
    FIGURE 7.

    Total-body dynamic imaging. (Top) Selections of rotating MIPs from dynamic scan of subject 2. Frame duration is 1 s, except for the 2 left-most images, which have frame durations of 1 min. (Bottom) Time–activity curves for selected anatomic regions. (Bottom inset) Time–activity curves for first minute of acquisition.

Tables

  • TABLE 1

    Subject Demographics and Injected Activity

    SubjectSexAge (y)Weight (kg)Height (cm)Blood glucose level (mmol/L)Injected activity (MBq)
    1Male6165163.54.9290 (7.8)
    2Female6156156.04.8256 (6.9)
    3Female6355150.04.381 (2.2)
    4Female4543.5152.05.125 (0.68)

    • Data in parentheses are mCi.

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