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Research ArticleThe State of the Art

First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*

Ramsey D. Badawi, Hongcheng Shi, Pengcheng Hu, Shuguang Chen, Tianyi Xu, Patricia M. Price, Yu Ding, Benjamin A. Spencer, Lorenzo Nardo, Weiping Liu, Jun Bao, Terry Jones, Hongdi Li and Simon R. Cherry
Journal of Nuclear Medicine March 2019, 60 (3) 299-303; DOI: https://doi.org/10.2967/jnumed.119.226498
Ramsey D. Badawi
1Department of Radiology, University of California Davis Medical Center, Sacramento, California
2Department of Biomedical Engineering, University of California, Davis, California
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Hongcheng Shi
3Department of Nuclear Medicine, Zhongshan Hospital Fudan University, Shanghai, China
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Pengcheng Hu
3Department of Nuclear Medicine, Zhongshan Hospital Fudan University, Shanghai, China
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Shuguang Chen
3Department of Nuclear Medicine, Zhongshan Hospital Fudan University, Shanghai, China
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Tianyi Xu
4United Imaging Healthcare, Shanghai, China; and
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Patricia M. Price
5Department of Surgery and Cancer, Imperial College, London, United Kingdom
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Yu Ding
4United Imaging Healthcare, Shanghai, China; and
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Benjamin A. Spencer
1Department of Radiology, University of California Davis Medical Center, Sacramento, California
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Lorenzo Nardo
1Department of Radiology, University of California Davis Medical Center, Sacramento, California
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Weiping Liu
4United Imaging Healthcare, Shanghai, China; and
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Jun Bao
4United Imaging Healthcare, Shanghai, China; and
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Terry Jones
1Department of Radiology, University of California Davis Medical Center, Sacramento, California
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Hongdi Li
4United Imaging Healthcare, Shanghai, China; and
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Simon R. Cherry
1Department of Radiology, University of California Davis Medical Center, Sacramento, California
2Department of Biomedical Engineering, University of California, Davis, California
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Abstract

Within the EXPLORER Consortium, the construction of the world’s first total-body PET/CT scanner has recently been completed. The 194-cm axial field of view of the EXPLORER PET/CT scanner is sufficient to cover, for the first time, the entire human adult body in a single acquisition in more than 99% of the population and allows total-body pharmacokinetic studies with frame durations as short as 1 s. The large increase in sensitivity arising from total-body coverage as well as increased solid angle for detection at any point within the body allows whole-body 18F-FDG PET studies to be acquired with unprecedented count density, improving the signal-to-noise ratio of the resulting images. Alternatively, the sensitivity gain can be used to acquire diagnostic PET images with very small amounts of activity in the field of view (25 MBq, 0.7 mCi or less), with very short acquisition times (∼1 min or less) or at later time points after the tracer’s administration. We report here on the first human imaging studies on the EXPLORER scanner using a range of different protocols that provide initial evidence in support of these claims. These case studies provide the foundation for future carefully controlled trials to quantitatively evaluate the improvements possible through total-body PET imaging.

  • instrumentation
  • PET
  • EXPLORER
  • FDG
  • PET/CT
  • total-body PET

Footnotes

  • The manuscript by Badawi et al. is an unusual selection for a State-of-the-Art contribution. It is communicating the exquisite quality of PET images acquired with the total-body EXPLORER system. As these are the best PET images ever acquired, we felt that this should be considered as a State-of-the-Art review. A discussion with Dr. Simon Cherry on page 295 provides more conceptual details and background information.

  • Published online Feb. 7, 2019.

  • © 2019 by the Society of Nuclear Medicine and Molecular Imaging.
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Journal of Nuclear Medicine: 60 (3)
Journal of Nuclear Medicine
Vol. 60, Issue 3
March 1, 2019
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First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*
Ramsey D. Badawi, Hongcheng Shi, Pengcheng Hu, Shuguang Chen, Tianyi Xu, Patricia M. Price, Yu Ding, Benjamin A. Spencer, Lorenzo Nardo, Weiping Liu, Jun Bao, Terry Jones, Hongdi Li, Simon R. Cherry
Journal of Nuclear Medicine Mar 2019, 60 (3) 299-303; DOI: 10.2967/jnumed.119.226498

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First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*
Ramsey D. Badawi, Hongcheng Shi, Pengcheng Hu, Shuguang Chen, Tianyi Xu, Patricia M. Price, Yu Ding, Benjamin A. Spencer, Lorenzo Nardo, Weiping Liu, Jun Bao, Terry Jones, Hongdi Li, Simon R. Cherry
Journal of Nuclear Medicine Mar 2019, 60 (3) 299-303; DOI: 10.2967/jnumed.119.226498
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  • Article
    • Abstract
    • EXPLORER SCANNER
    • HUMAN SUBJECTS
    • HIGH-QUALITY IMAGING
    • REDUCED SCAN TIME
    • DELAYED IMAGING
    • LOW-DOSE IMAGING
    • SINGLE-ORGAN IMAGING
    • TOTAL-BODY DYNAMIC IMAGING
    • CONCLUSION
    • DISCLOSURE
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Keywords

  • Instrumentation
  • PET
  • EXPLORER
  • FDG
  • PET/CT
  • total-body PET
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