Research ArticleNeurology
Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles
Talakad G. Lohith, Idriss Bennacef, Rik Vandenberghe, Mathieu Vandenbulcke, Cristian A. Salinas, Ruben Declercq, Tom Reynders, N. Florestina Telan-Choing, Kerry Riffel, Sofie Celen, Kim Serdons, Guy Bormans, Kuenhi Tsai, Abbas Walji, Eric D. Hostetler, Jeffrey L. Evelhoch, Koen Van Laere, Mark Forman, Aubrey Stoch, Cyrille Sur and Arie Struyk
Journal of Nuclear Medicine January 2019, 60 (1) 107-114; DOI: https://doi.org/10.2967/jnumed.118.208215
Talakad G. Lohith
1Translational Biomarkers, Merck & Co., Inc., West Point, Pennsylvania
Idriss Bennacef
1Translational Biomarkers, Merck & Co., Inc., West Point, Pennsylvania
Rik Vandenberghe
2Neurology Department, University Hospitals Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium; Alzheimer Research Centre, KU Leuven, Leuven Institute for Neuroscience and Disease, Leuven, Belgium
Mathieu Vandenbulcke
2Neurology Department, University Hospitals Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium; Alzheimer Research Centre, KU Leuven, Leuven Institute for Neuroscience and Disease, Leuven, Belgium
Cristian A. Salinas
1Translational Biomarkers, Merck & Co., Inc., West Point, Pennsylvania
Ruben Declercq
3Translational Pharmacology Europe, Merck Sharp & Dohme Corp., Brussels, Belgium
Tom Reynders
3Translational Pharmacology Europe, Merck Sharp & Dohme Corp., Brussels, Belgium
N. Florestina Telan-Choing
4Translational Pharmacology Clinical Operations, Merck & Co., Inc., North Wales, Pennsylvania
Kerry Riffel
1Translational Biomarkers, Merck & Co., Inc., West Point, Pennsylvania
Sofie Celen
5Radiopharmaceutical Research, KU Leuven, Leuven, Belgium
Kim Serdons
6Division of Nuclear Medicine, University Hospitals Leuven and UZ Leuven, Leuven, Belgium
Guy Bormans
5Radiopharmaceutical Research, KU Leuven, Leuven, Belgium
Kuenhi Tsai
7Early Clinical Statistics, Merck & Co., Inc., West Point, Pennsylvania
Abbas Walji
8Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania; and
Eric D. Hostetler
1Translational Biomarkers, Merck & Co., Inc., West Point, Pennsylvania
Jeffrey L. Evelhoch
1Translational Biomarkers, Merck & Co., Inc., West Point, Pennsylvania
Koen Van Laere
6Division of Nuclear Medicine, University Hospitals Leuven and UZ Leuven, Leuven, Belgium
Mark Forman
9Translational Pharmacology, Merck & Co., Inc., North Wales, Pennsylvania
Aubrey Stoch
9Translational Pharmacology, Merck & Co., Inc., North Wales, Pennsylvania
Cyrille Sur
1Translational Biomarkers, Merck & Co., Inc., West Point, Pennsylvania
Arie Struyk
9Translational Pharmacology, Merck & Co., Inc., North Wales, Pennsylvania
Data supplements
Supplemental Data
Files in this Data Supplement:
In this issue
Journal of Nuclear Medicine
Vol. 60, Issue 1
January 1, 2019
Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles
Talakad G. Lohith, Idriss Bennacef, Rik Vandenberghe, Mathieu Vandenbulcke, Cristian A. Salinas, Ruben Declercq, Tom Reynders, N. Florestina Telan-Choing, Kerry Riffel, Sofie Celen, Kim Serdons, Guy Bormans, Kuenhi Tsai, Abbas Walji, Eric D. Hostetler, Jeffrey L. Evelhoch, Koen Van Laere, Mark Forman, Aubrey Stoch, Cyrille Sur, Arie Struyk
Journal of Nuclear Medicine Jan 2019, 60 (1) 107-114; DOI: 10.2967/jnumed.118.208215
Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles
Talakad G. Lohith, Idriss Bennacef, Rik Vandenberghe, Mathieu Vandenbulcke, Cristian A. Salinas, Ruben Declercq, Tom Reynders, N. Florestina Telan-Choing, Kerry Riffel, Sofie Celen, Kim Serdons, Guy Bormans, Kuenhi Tsai, Abbas Walji, Eric D. Hostetler, Jeffrey L. Evelhoch, Koen Van Laere, Mark Forman, Aubrey Stoch, Cyrille Sur, Arie Struyk
Journal of Nuclear Medicine Jan 2019, 60 (1) 107-114; DOI: 10.2967/jnumed.118.208215
Jump to section
Related Articles
Cited By...
- Cryo-EM structure of Alzheimers disease tau filaments with PET ligand MK-6240
- Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging
- The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [18F]MK6240 Tau PET in Target Regions
- Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management
- The association of age-related and off-target retention with longitudinal quantification of [18F]MK6240 tau-PET in target regions
- Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects
- TauIQ: A Canonical Image Based Algorithm to Quantify Tau PET Scans
- Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimers Disease
- Olfactory impairment is related to tau pathology and neuroinflammation in Alzheimers disease
- In vivo synaptic density loss is related to tau deposition in amnestic mild cognitive impairment