Abstract
1295
Objectives: Lung cancer is a common malignant tumor in the world, whose incidence and mortality has increased year by year, and lung adenocarcinoma is the most common pathological type of lung cancer. ATAD2 (ATPase family AAA domain-containing protein 2), a member of the AAA+ATPase family of proteins, contains both an ATPase domain and a bromodomain. Studies have revealed that ATAD2 is highly expressed in several types of tumors. The purpose of this study was to investigate the correlation between ATAD2 expression of lung adenocarcinoma and the semi-quantitative index of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging including maximum standard uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG).
Methods: The patients who taken 18F-FDG PET/CT imaging preoperative, and were under the pathological diagnosis of lung adenocarcinoma were included, among whom 59 cases (male 30 cases, female 29 cases, average age 60.56±9.65 years) were selected finally. The SP immunohistochemical method was employed to determine the expression of ATAD2 in 59 cases of lung adenocarcinoma tissue and 46 cases of para-carcinoma lung tissue. Compare the difference of ATAD2 expression between lung adenocarcinoma tissue and para-carcinoma lung tissue. The correlation between the expression of ATAD2 in the lung adenocarcinoma and the the semi-quantitative index of 18F-FDG PET/CT imaging including SUVmax, MTV and TLG was analyzed by Spearman correlation analysis.
Results: According to the immunohistochemical, the expression of ATAD2 in 59 cases of lung adenocarcinoma tissue was significantly higher than that in 46 cases of para-carcinoma lung tissue (P<0.01). The expression level of ATAD2 in lung adenocarcinoma showed a significant positive correlation with semi quantitative index of 18F-FDG PET/CT imaging, such as SUVmax and TLG(rho=0.824, 0.623, P<0.01), while there is no significant correlation between the MTV and the expression of ATAD2 in lung adenocarcinoma (rho=0.095, P>0.05).
Conclusions: The expression of ATAD2 in lung adenocarcinoma tissue was significantly higher than that in para-carcinoma lung tissue. The expression level of ATAD2 in lung adenocarcinoma showed a significant positive correlation with SUVmax and TLG, which showed 18F-FDG PET/CT imaging might be used as an effective imaging method to provide more clinical information during the diagnosis and treatment of lung adenocarcinoma.