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Research ArticleTranslational

Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein

Thomas Lindner, Anastasia Loktev, Annette Altmann, Frederik Giesel, Clemens Kratochwil, Jürgen Debus, Dirk Jäger, Walter Mier and Uwe Haberkorn
Journal of Nuclear Medicine September 2018, 59 (9) 1415-1422; DOI: https://doi.org/10.2967/jnumed.118.210443
Thomas Lindner
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Anastasia Loktev
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
2Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
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Annette Altmann
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
2Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Frederik Giesel
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Clemens Kratochwil
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Jürgen Debus
4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
5Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and
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Dirk Jäger
6Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany
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Walter Mier
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Uwe Haberkorn
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
2Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Article Information

vol. 59 no. 9 1415-1422
DOI 
https://doi.org/10.2967/jnumed.118.210443
PubMed 
29626119

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 23, 2018
  • Accepted for publication March 22, 2018
  • Published online September 4, 2018.

Article Versions

  • previous version (April 6, 2018 - 09:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2018 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Thomas Lindner*,1,
  2. Anastasia Loktev*,1–3,
  3. Annette Altmann1,2,
  4. Frederik Giesel1,
  5. Clemens Kratochwil1,
  6. Jürgen Debus4,5,
  7. Dirk Jäger6,
  8. Walter Mier1 and
  9. Uwe Haberkorn1,2
  1. 1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
  2. 2Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
  3. 3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
  4. 4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
  5. 5Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and
  6. 6Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany
  1. For correspondence or reprints contact: Uwe Haberkorn, Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. E-mail: uwe.haberkorn{at}med.uni-heidelberg.de
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 59 (9)
Journal of Nuclear Medicine
Vol. 59, Issue 9
September 1, 2018
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Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein
Thomas Lindner, Anastasia Loktev, Annette Altmann, Frederik Giesel, Clemens Kratochwil, Jürgen Debus, Dirk Jäger, Walter Mier, Uwe Haberkorn
Journal of Nuclear Medicine Sep 2018, 59 (9) 1415-1422; DOI: 10.2967/jnumed.118.210443

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Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein
Thomas Lindner, Anastasia Loktev, Annette Altmann, Frederik Giesel, Clemens Kratochwil, Jürgen Debus, Dirk Jäger, Walter Mier, Uwe Haberkorn
Journal of Nuclear Medicine Sep 2018, 59 (9) 1415-1422; DOI: 10.2967/jnumed.118.210443
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Keywords

  • oncology
  • PET
  • Radiopharmaceuticals
  • FAP
  • small molecules
  • Theranostic
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