Abstract
The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. α-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of α-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of α-emitters in preclinical and clinical studies.
Footnotes
Published online Mar. 1, 2018.
Learning Objectives: On successful completion of this activity, participants should be able to (1) match α-emitters to potential vectors or targets of interest; (2) highlight the potential of α-emitters in preclinical work; and (3) identify the current clinical uses of α-emitters and the importance of clinical trial design for broader application of α-therapy.
Financial Disclosure: This work is supported by the Radiochemistry and Molecular Imaging Probe Core, which is supported in part by NIH/NCI Cancer Center Support Grant P30 CA008748. Jason Lewis is supported by the Mr. William H. and Mrs. Alice Goodwin and the Commonwealth Foundation for Cancer Research and by the Center for Experimental Therapeutics of Memorial Sloan Kettering Cancer Center. Sophie Poty is supported by the François Wallace Monahan Fellowship from the JLM Benevolent Fund. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest.
CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsr continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, SAM, and other credit types, participants can access this activity through the SNMMI website (http://www.snmmilearningcenter.org) through July 2021.
- © 2018 by the Society of Nuclear Medicine and Molecular Imaging.