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Research ArticleNeurology

Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities

Alex Whittington, David J. Sharp and Roger N. Gunn; for the Alzheimer’s Disease Neuroimaging Initiative
Journal of Nuclear Medicine May 2018, 59 (5) 822-827; DOI: https://doi.org/10.2967/jnumed.117.194720
Alex Whittington
1Division of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
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David J. Sharp
1Division of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
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Roger N. Gunn
1Division of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
2Imanova Ltd., London, United Kingdom; and
3Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
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Abstract

β-amyloid (Aβ) accumulation in the brain is 1 of 2 pathologic hallmarks of Alzheimer disease (AD), and the spatial distribution of Aβ has been studied extensively ex vivo. Methods: We applied mathematical modeling to Aβ in vivo PET imaging data to investigate competing theories of Aβ spread in AD. Results: Our results provided evidence that Aβ accumulation starts in all brain regions simultaneously and that its spatiotemporal distribution is due to heterogeneous regional carrying capacities (regional maximum possible concentration of Aβ) for the aggregated protein rather than to longer-term spreading from seed regions. Conclusion: The in vivo spatiotemporal distribution of Aβ in AD can be mathematically modeled using a logistic growth model in which the Aβ carrying capacity is heterogeneous across the brain but the exponential growth rate and time of half maximal Aβ concentration are constant.

  • image processing
  • PET/CT
  • β-amyloid
  • Alzheimer disease
  • mathematical modeling
  • neuroimaging

Footnotes

  • Published online Nov. 16, 2017.

  • © 2018 by the Society of Nuclear Medicine and Molecular Imaging.
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Journal of Nuclear Medicine: 59 (5)
Journal of Nuclear Medicine
Vol. 59, Issue 5
May 1, 2018
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Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities
Alex Whittington, David J. Sharp, Roger N. Gunn
Journal of Nuclear Medicine May 2018, 59 (5) 822-827; DOI: 10.2967/jnumed.117.194720

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Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities
Alex Whittington, David J. Sharp, Roger N. Gunn
Journal of Nuclear Medicine May 2018, 59 (5) 822-827; DOI: 10.2967/jnumed.117.194720
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Keywords

  • Image Processing
  • PET/CT
  • β-amyloid
  • Alzheimer disease
  • mathematical modeling
  • neuroimaging
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