Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

Michael Honer; Luca Gobbi; Henner Knust; Hiroto Kuwabara; Dieter Muri; Matthias Koerner; Heather Valentine; Robert F. Dannals; Dean F. Wong; Edilio Borroni

doi:10.2967/jnumed.117.196741

Research ArticleNeurology

Preclinical Evaluation of ¹⁸F-RO6958948, ¹¹C-RO6931643, and ¹¹C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

Michael Honer, Luca Gobbi, Henner Knust, Hiroto Kuwabara, Dieter Muri, Matthias Koerner, Heather Valentine, Robert F. Dannals, Dean F. Wong and Edilio Borroni

Journal of Nuclear Medicine April 2018, 59 (4) 675-681; DOI: https://doi.org/10.2967/jnumed.117.196741

Michael Honer

1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Luca Gobbi

1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Henner Knust

1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Hiroto Kuwabara

2PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

3Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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Dieter Muri

1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Matthias Koerner

1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Heather Valentine

2PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

3Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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Robert F. Dannals

2PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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Dean F. Wong

2PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

3Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

4Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland

5Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland; and

6Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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Edilio Borroni

1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Journal of Nuclear Medicine

Vol. 59, Issue 4

April 1, 2018

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Preclinical Evaluation of ¹⁸F-RO6958948, ¹¹C-RO6931643, and ¹¹C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

Michael Honer, Luca Gobbi, Henner Knust, Hiroto Kuwabara, Dieter Muri, Matthias Koerner, Heather Valentine, Robert F. Dannals, Dean F. Wong, Edilio Borroni

Journal of Nuclear Medicine Apr 2018, 59 (4) 675-681; DOI: 10.2967/jnumed.117.196741

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Preclinical Evaluation of ¹⁸F-RO6958948, ¹¹C-RO6931643, and ¹¹C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

Michael Honer, Luca Gobbi, Henner Knust, Hiroto Kuwabara, Dieter Muri, Matthias Koerner, Heather Valentine, Robert F. Dannals, Dean F. Wong, Edilio Borroni

Journal of Nuclear Medicine Apr 2018, 59 (4) 675-681; DOI: 10.2967/jnumed.117.196741

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tauopathy
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Alzheimer disease

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Preclinical Evaluation of ¹⁸F-RO6958948, ¹¹C-RO6931643, and ¹¹C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

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