Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer

Sarah M. Cheal; Edward K. Fung; Mitesh Patel; Hong Xu; Hong-fen Guo; Pat B. Zanzonico; Sebastien Monette; K. Dane Wittrup; Nai-Kong V. Cheung; Steven M. Larson

doi:10.2967/jnumed.117.193250

Research ArticleOncology

Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer

Sarah M. Cheal, Edward K. Fung, Mitesh Patel, Hong Xu, Hong-fen Guo, Pat B. Zanzonico, Sebastien Monette, K. Dane Wittrup, Nai-Kong V. Cheung and Steven M. Larson

Journal of Nuclear Medicine November 2017, 58 (11) 1735-1742; DOI: https://doi.org/10.2967/jnumed.117.193250

Sarah M. Cheal

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

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Edward K. Fung

3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York

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Mitesh Patel

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

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Hong Xu

4Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York

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Hong-fen Guo

4Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York

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Pat B. Zanzonico

3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York

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Sebastien Monette

5Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, New York

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K. Dane Wittrup

6Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts

7Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; and

8Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts

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Nai-Kong V. Cheung

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

4Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York

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Steven M. Larson

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

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Journal of Nuclear Medicine

Vol. 58, Issue 11

November 1, 2017

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Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer

Sarah M. Cheal, Edward K. Fung, Mitesh Patel, Hong Xu, Hong-fen Guo, Pat B. Zanzonico, Sebastien Monette, K. Dane Wittrup, Nai-Kong V. Cheung, Steven M. Larson

Journal of Nuclear Medicine Nov 2017, 58 (11) 1735-1742; DOI: 10.2967/jnumed.117.193250

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Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer

Sarah M. Cheal, Edward K. Fung, Mitesh Patel, Hong Xu, Hong-fen Guo, Pat B. Zanzonico, Sebastien Monette, K. Dane Wittrup, Nai-Kong V. Cheung, Steven M. Larson

Journal of Nuclear Medicine Nov 2017, 58 (11) 1735-1742; DOI: 10.2967/jnumed.117.193250

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pretargeting
colorectal cancer
radioimmunotherapy
SPECT

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Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer

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