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Review ArticleContinuing Education

PSMA Ligands for PET Imaging of Prostate Cancer

Sarah M. Schwarzenboeck, Isabel Rauscher, Christina Bluemel, Wolfgang P. Fendler, Steven P. Rowe, Martin G. Pomper, Ali Asfhar-Oromieh, Ken Herrmann and Matthias Eiber
Journal of Nuclear Medicine October 2017, 58 (10) 1545-1552; DOI: https://doi.org/10.2967/jnumed.117.191031
Sarah M. Schwarzenboeck
1Department of Nuclear Medicine, Rostock University Medical Centre, Rostock, Germany
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Isabel Rauscher
2Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
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Christina Bluemel
3Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany
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Wolfgang P. Fendler
4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California
5Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany
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Steven P. Rowe
6Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Martin G. Pomper
6Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Ali Asfhar-Oromieh
7Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany
8Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Centre, Heidelberg, Germany; and
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Ken Herrmann
4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California
9Klinik für Nuklearmedizin, Universitätsklinikum Essen, Essen, Germany
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Matthias Eiber
2Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California
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  • FIGURE 1.
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    FIGURE 1.

    A 63-y-old patient with biochemical recurrence (PSA of 0.21 ng/mL) after radical prostatectomy (initially pT2c N0 M0 L1/V1 R1 G1, Gleason score of 7), local radiation treatment, and antiandrogen therapy. 68Ga-PSMA ligand PET/CT exhibits solitary left iliac radiotracer-positive lymph node (arrow). Shown are transaxial CT (A), PET (B), and fused PET/CT (C) images. Patient was referred for salvage lymph node dissection.

  • FIGURE 2.
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    FIGURE 2.

    A 78-y-old patient with biochemical recurrence (PSA of 0.54 ng/mL) after radical prostatectomy (initially pT3b N0 M0 R0 G2). 68Ga-PSMA ligand PET/CT reveals focal uptake in left paramedian prostatic fossa, indicating local recurrence. Shown are transaxial CT (A), PET (B), and fused PET/CT (C) images. Patient was referred for salvage radiation treatment.

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    FIGURE 3.

    Maximum-intensity-protection images (acquired with 18F-DCFBC [A] and 18F-DCFPyL [B]) displaying typical PSMA ligand biodistribution. Physiologic accumulation is seen in lacrimal and salivary glands, nasal mucosa, liver, spleen, bowel, kidneys, ureter on right side, and bladder.

  • FIGURE 4.
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    FIGURE 4.

    Transaxial CT (A), PET (B), and fused PET/CT (C) 68Ga-PSMA ligand scans demonstrating moderate, focal PSMA ligand uptake (arrows) in comma-shaped soft-tissue structure between left adrenal gland and aorta, indicating normal variant uptake in celiac ganglion.

  • FIGURE 5.
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    FIGURE 5.

    68Ga-PSMA ligand PET/CT scan exhibiting moderate, focal PSMA ligand uptake in left rib on transaxial PET (B) and fused PET/CT (D) images. (A and C) Corresponding CT images confirm minimally displaced fracture of rib.

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Journal of Nuclear Medicine: 58 (10)
Journal of Nuclear Medicine
Vol. 58, Issue 10
October 1, 2017
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PSMA Ligands for PET Imaging of Prostate Cancer
Sarah M. Schwarzenboeck, Isabel Rauscher, Christina Bluemel, Wolfgang P. Fendler, Steven P. Rowe, Martin G. Pomper, Ali Asfhar-Oromieh, Ken Herrmann, Matthias Eiber
Journal of Nuclear Medicine Oct 2017, 58 (10) 1545-1552; DOI: 10.2967/jnumed.117.191031

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PSMA Ligands for PET Imaging of Prostate Cancer
Sarah M. Schwarzenboeck, Isabel Rauscher, Christina Bluemel, Wolfgang P. Fendler, Steven P. Rowe, Martin G. Pomper, Ali Asfhar-Oromieh, Ken Herrmann, Matthias Eiber
Journal of Nuclear Medicine Oct 2017, 58 (10) 1545-1552; DOI: 10.2967/jnumed.117.191031
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  • Article
    • Abstract
    • MAIN CLINICAL INDICATIONS OF PSMA LIGAND PET/CT AND CURRENT EVIDENCE IN THE LITERATURE
    • IMPACT ON TREATMENT PLANNING
    • PATIENT PREPARATION AND PSMA LIGAND PET/CT IMAGE ACQUISITION
    • PRACTICAL ISSUES
    • CONCLUSION
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  • Bridging the Imaging Gap: PSMA PET/CT Has a High Impact on Treatment Planning in Prostate Cancer Patients with Biochemical Recurrence--A Narrative Review of the Literature
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  • Comparison of 68Ga-PSMA-11 and 18F-Fluciclovine PET/CT in a Case Series of 10 Patients with Prostate Cancer Recurrence
  • Synthesis and Binding of a Novel PSMA-specific Conjugate
  • Impact of 68Ga-PSMA-11 PET/CT on the Management of Prostate Cancer Patients with Biochemical Recurrence
  • PSMA PET: Transformational Change in Prostate Cancer Management?
  • 68Ga-PSMA-11 PET/CT Mapping of Prostate Cancer Biochemical Recurrence After Radical Prostatectomy in 270 Patients with a PSA Level of Less Than 1.0 ng/mL: Impact on Salvage Radiotherapy Planning
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Keywords

  • prostate cancer
  • PET/CT
  • PSMA
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