Journal of Nuclear Medicine: 58 (10)

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October 1, 2017; Volume 58,Issue 10

This Month in JNM

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This Month in JNM
Journal of Nuclear Medicine October 1, 2017, 58 (10) 7A;

Editor’s Page

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Is 16 Months of Specialized Nuclear Medicine Training Enough for Best Patient Care?
Johannes Czernin

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1535;

Hot Topics

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Nuclear Medicine Training: What Now?
David Mankoff and Daniel A. Pryma

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1536-1538; DOI: https://doi.org/10.2967/jnumed.117.190132

The State of the Art

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¹⁸F-FDG PET/CT in Lymphoma: Has Imaging-Directed Personalized Medicine Become a Reality?
Sally F. Barrington and Peter W.M. Johnson

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1539-1544; DOI: https://doi.org/10.2967/jnumed.116.181347

Continuing Education

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PSMA Ligands for PET Imaging of Prostate Cancer
Sarah M. Schwarzenboeck, Isabel Rauscher, Christina Bluemel, Wolfgang P. Fendler, Steven P. Rowe, Martin G. Pomper, Ali Asfhar-Oromieh, Ken Herrmann and Matthias Eiber

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1545-1552; DOI: https://doi.org/10.2967/jnumed.117.191031

Focus on Molecular Imaging

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Pretargeted Imaging and Therapy
Mohamed Altai, Rosemery Membreno, Brendon Cook, Vladimir Tolmachev and Brian M. Zeglis

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1553-1559; DOI: https://doi.org/10.2967/jnumed.117.189944

Oncology

Basic
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  Imaging of Programmed Cell Death Ligand 1: Impact of Protein Concentration on Distribution of Anti-PD-L1 SPECT Agents in an Immunocompetent Murine Model of Melanoma
  Jessie R. Nedrow, Anders Josefsson, Sunju Park, Sagar Ranka, Sanchita Roy and George Sgouros
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1560-1566; DOI: https://doi.org/10.2967/jnumed.117.193268
Translational
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  ¹⁸F-Fluoromisonidazole Kinetic Modeling for Characterization of Tumor Perfusion and Hypoxia in Response to Antiangiogenic Therapy
  Milan Grkovski, Sally-Ann Emmas and Sean D. Carlin
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1567-1573; DOI: https://doi.org/10.2967/jnumed.117.190892
Clinical
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  In Vivo Relationship Between Hypoxia and Angiogenesis in Human Glioblastoma: A Multimodal Imaging Study
  Keven Ferreira da Ponte, David Hassanein Berro, Solène Collet, Jean-Marc Constans, Evelyne Emery, Samuel Valable and Jean-Sébastien Guillamo
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1574-1579; DOI: https://doi.org/10.2967/jnumed.116.188557
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  Improved Detection of Transosseous Meningiomas Using ⁶⁸Ga-DOTATATE PET/CT Compared with Contrast-Enhanced MRI
  Wolfgang G. Kunz, Lisa M. Jungblut, Philipp M. Kazmierczak, Franziska J. Vettermann, Andreas Bollenbacher, Jörg C. Tonn, Christian Schichor, Axel Rominger, Nathalie L. Albert, Peter Bartenstein, Maximilian F. Reiser and Clemens C. Cyran
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1580-1587; DOI: https://doi.org/10.2967/jnumed.117.191932
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  Alternative Means of Estimating ¹³¹I Maximum Permissible Activity to Treat Thyroid Cancer
  Kenneth J. Nichols, William Robeson, Miyuki Yoshida-Hay, Pat B. Zanzonico, Fritzgerald Leveque, Kuldeep K. Bhargava, Gene G. Tronco and Christopher J. Palestro
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1588-1595; DOI: https://doi.org/10.2967/jnumed.117.192278
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  Reader Training for the Restaging of Biochemically Recurrent Prostate Cancer Using ¹⁸F-Fluciclovine PET/CT
  Matthew P. Miller, Lale Kostakoglu, Daniel Pryma, Jian Qin Yu, Albert Chau, Eric Perlman, Bonnie Clarke, Donald Rosen and Penelope Ward
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1596-1602; DOI: https://doi.org/10.2967/jnumed.116.188375
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  Assessing Bone Marrow Activity in Patients with Myelofibrosis: Results of a Pilot Study of ¹⁸F-FLT PET
  Laetitia Vercellino, Matthieu John Ouvrier, Emmanuelle Barré, Bruno Cassinat, Virginie de Beco, Christine Dosquet, Sylvie Chevret, Véronique Meignin, Christine Chomienne, Marie-Elisabeth Toubert, Pascal Merlet and Jean-Jacques Kiladjian
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1603-1608; DOI: https://doi.org/10.2967/jnumed.116.188508

Theranostics

Basic
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  SSTR-Mediated Imaging in Breast Cancer: Is There a Role for Radiolabeled Somatostatin Receptor Antagonists?
  Simone U. Dalm, Joost Haeck, Gabriela N. Doeswijk, Erik de Blois, Marion de Jong and Carolien H.M. van Deurzen
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1609-1614; DOI: https://doi.org/10.2967/jnumed.116.189035
Clinical
- INVITED PERSPECTIVE
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    Accuracy in the Eye of the Beholder: Can We Improve Agreement in Prostate Cancer Diagnostics with PSMA PET/CT?
    Michael S. Hofman
    
    Journal of Nuclear Medicine October 1, 2017, 58 (10) 1615-1616; DOI: https://doi.org/10.2967/jnumed.117.192542
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  ⁶⁸Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study
  Wolfgang Peter Fendler, Jeremie Calais, Martin Allen-Auerbach, Christina Bluemel, Nina Eberhardt, Louise Emmett, Pawan Gupta, Markus Hartenbach, Thomas A. Hope, Shozo Okamoto, Christian Helmut Pfob, Thorsten D. Pöppel, Christoph Rischpler, Sarah Schwarzenböck, Vanessa Stebner, Marcus Unterrainer, Helle D. Zacho, Tobias Maurer, Christian Gratzke, Alexander Crispin, Johannes Czernin, Ken Herrmann and Matthias Eiber
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1617-1623; DOI: https://doi.org/10.2967/jnumed.117.190827
- FEATURED ARTICLE OF THE MONTH
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    Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with ²²⁵Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding
    Clemens Kratochwil, Frank Bruchertseifer, Hendrik Rathke, Marcus Bronzel, Christos Apostolidis, Wilko Weichert, Uwe Haberkorn, Frederik L. Giesel and Alfred Morgenstern
    
    Journal of Nuclear Medicine October 1, 2017, 58 (10) 1624-1631; DOI: https://doi.org/10.2967/jnumed.117.191395
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  Exploring New Multimodal Quantitative Imaging Indices for the Assessment of Osseous Tumor Burden in Prostate Cancer Using ⁶⁸Ga-PSMA PET/CT
  Marie Bieth, Markus Krönke, Robert Tauber, Marielena Dahlbender, Margitta Retz, Stephan G. Nekolla, Bjoern Menze, Tobias Maurer, Matthias Eiber and Markus Schwaiger
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1632-1637; DOI: https://doi.org/10.2967/jnumed.116.189050

Cardiology

Translational
- FEATURED TRANSLATIONAL SCIENCE ARTICLE
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    Doxorubicin Effect on Myocardial Metabolism as a Prerequisite for Subsequent Development of Cardiac Toxicity: A Translational ¹⁸F-FDG PET/CT Observation
    Matteo Bauckneht, Giulia Ferrarazzo, Francesco Fiz, Silvia Morbelli, Matteo Sarocchi, Fabio Pastorino, Alberto Ghidella, Elena Pomposelli, Maurizio Miglino, Pietro Ameri, Laura Emionite, Flavia Ticconi, Eleonora Arboscello, Ambra Buschiazzo, Elena Augusta Massimelli, Salvatore Fiordoro, Anna Borra, Vanessa Cossu, Annalisa Bozzano, Adalberto Ibatici, Mirco Ponzoni, Paolo Spallarossa, Andrea Gallamini, Paolo Bruzzi, Gianmario Sambuceti and Cecilia Marini
    
    Journal of Nuclear Medicine October 1, 2017, 58 (10) 1638-1645; DOI: https://doi.org/10.2967/jnumed.117.191122

Neurology

Translational
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  Evaluation of the Effect of Fingolimod Treatment on Microglial Activation Using Serial PET Imaging in Multiple Sclerosis
  Marcus Sucksdorff, Eero Rissanen, Jouni Tuisku, Salla Nuutinen, Teemu Paavilainen, Johanna Rokka, Juha Rinne and Laura Airas
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1646-1651; DOI: https://doi.org/10.2967/jnumed.116.183020

Molecular Imaging

Basic
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  High-Contrast PET Imaging of Vasopressin V_1B Receptors with a Novel Radioligand, ¹¹C-TASP699
  Kazumi Koga, Yuji Nagai, Masayuki Hanyu, Mitsukane Yoshinaga, Shigeyuki Chaki, Norikazu Ohtake, Satoshi Ozaki, Ming-Rong Zhang, Tetsuya Suhara and Makoto Higuchi
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1652-1658; DOI: https://doi.org/10.2967/jnumed.116.188698
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  Molecular Imaging of Human Embryonic Stem Cells Stably Expressing Human PET Reporter Genes After Zinc Finger Nuclease–Mediated Genome Editing
  Esther Wolfs, Bryan Holvoet, Laura Ordovas, Natacha Breuls, Nicky Helsen, Matthias Schönberger, Susanna Raitano, Tom Struys, Bert Vanbilloen, Cindy Casteels, Maurilio Sampaolesi, Koen Van Laere, Ivo Lambrichts, Catherine M. Verfaillie and Christophe M. Deroose
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1659-1665; DOI: https://doi.org/10.2967/jnumed.117.189779
Clinical
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  ¹⁸F-Tetrafluoroborate, a PET Probe for Imaging Sodium/Iodide Symporter Expression: Whole-Body Biodistribution, Safety, and Radiation Dosimetry in Thyroid Cancer Patients
  Jim O’Doherty, Maite Jauregui-Osoro, Teresa Brothwood, Teresa Szyszko, Paul K. Marsden, Michael J. O’Doherty, Gary J.R. Cook, Philip J. Blower and Val Lewington
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1666-1671; DOI: https://doi.org/10.2967/jnumed.117.192252

Radiation Biology

Clinical
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  Three-Dimensional Dosimetry for Radiation Safety Estimates from Intrathecal Administration
  Jacob Y. Hesterman, Susan D. Kost, Robert W. Holt, Howard Dobson, Ajay Verma and P. David Mozley
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1672-1678; DOI: https://doi.org/10.2967/jnumed.117.190611

Imaging/Infection

Basic
- FEATURED BASIC SCIENCE ARTICLE
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    Specific Imaging of Bacterial Infection Using 6″-¹⁸F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria
    Gayatri Gowrishankar, Jonathan Hardy, Mirwais Wardak, Mohammad Namavari, Robert E. Reeves, Evgenios Neofytou, Ananth Srinivasan, Joseph C. Wu, Christopher H. Contag and Sanjiv Sam Gambhir
    
    Journal of Nuclear Medicine October 1, 2017, 58 (10) 1679-1684; DOI: https://doi.org/10.2967/jnumed.117.191452
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  Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with ¹²⁵I-Iodo-DPA-713 SPECT/CT
  Catherine A. Foss, Liansheng Liu, Ronnie C. Mease, Haofan Wang, Pankaj Pasricha and Martin G. Pomper
  
  Journal of Nuclear Medicine October 1, 2017, 58 (10) 1685-1690; DOI: https://doi.org/10.2967/jnumed.117.189571

Physics/Instrumentation

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Quantitative Evaluation of 2 Scatter-Correction Techniques for ¹⁸F-FDG Brain PET/MRI in Regard to MR-Based Attenuation Correction
Jarmo Teuho, Virva Saunavaara, Tuula Tolvanen, Terhi Tuokkola, Antti Karlsson, Jouni Tuisku and Mika Teräs

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1691-1698; DOI: https://doi.org/10.2967/jnumed.117.190231
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Simulation of Tracer Dose Reduction in ¹⁸F-FDG PET/MRI: Effects on Oncologic Reading, Image Quality, and Artifacts
Ferdinand Seith, Holger Schmidt, Julia Kunz, Thomas Küstner, Sergios Gatidis, Konstantin Nikolaou, Christian la Fougère and Nina Schwenzer

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1699-1705; DOI: https://doi.org/10.2967/jnumed.116.184440

Letters to the Editor

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Dual-Integrin α_vβ₃- and Gastrin-Releasing Peptide Receptor–Targeting PET Radiotracer (⁶⁸Ga-BBN-RGD)
Andrei Iagaru

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1706; DOI: https://doi.org/10.2967/jnumed.117.191478
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Reply: Dual-Integrin α_vβ₃- and Gastrin-Releasing Peptide Receptor–Targeting PET Radiotracer (⁶⁸Ga-BBN-RGD)
Xiaoyuan Chen

Journal of Nuclear Medicine October 1, 2017, 58 (10) 1706-1707; DOI: https://doi.org/10.2967/jnumed.117.198374

Errata

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Errata
Journal of Nuclear Medicine October 1, 2017, 58 (10) 1707;

SNMMI Newsline

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2017 SNMMI Highlights Lecture: Neuroscience
Alexander Drzezga

Journal of Nuclear Medicine October 1, 2017, 58 (10) 9N-15N;
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SNMMI Honors Contributors at 2017 Annual Meeting
Journal of Nuclear Medicine October 1, 2017, 58 (10) 17N-18N;
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Radioiodine Theranostics: Increasing Dialogue and Collaboration
Douglas Van Nostrand

Journal of Nuclear Medicine October 1, 2017, 58 (10) 19N-20N;
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SNMMI Leadership Update: SNMMI 2018 Mid-Winter Symposium in Orlando: Focus on Theranostics
Virginia Pappas

Journal of Nuclear Medicine October 1, 2017, 58 (10) 21N;

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About the Cover

This Month in JNM

Editor’s Page

Hot Topics

The State of the Art

Continuing Education

Focus on Molecular Imaging

Oncology

Basic

Translational

Clinical

Theranostics

Basic

Clinical

INVITED PERSPECTIVE

FEATURED ARTICLE OF THE MONTH

Cardiology

Translational

FEATURED TRANSLATIONAL SCIENCE ARTICLE

Neurology

Translational

Molecular Imaging

Basic

Clinical

Radiation Biology

Clinical

Imaging/Infection

Basic

FEATURED BASIC SCIENCE ARTICLE

Physics/Instrumentation

Letters to the Editor

Errata

SNMMI Newsline

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