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Journal of Nuclear Medicine

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About the Cover

January 1, 2017; Volume 58,Issue 1

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 8A;

SNMMI Newsline

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    2016 SNMMI Highlights Lecture: Oncology, Part 1
    Wolfgang A. Weber
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 9N-15N;
  • You have access
    SNMMI, ASNC, IAC and Nuclear Cardiology Dose
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 15N;
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    SNMMI COR Submits Recommendations, White Paper on Compounded Sterile Radiopharmaceuticals to USP
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 16N-17N;
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    NIH Doubles Investment in BRAIN Initiative
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 18N;
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    History Corner: Archive Project and History Fund
    Frederic Fahey
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 19N;
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    SNMMI Leadership Update: FDA Approval of Imaging Agents: An Exciting Investment in Nuclear Medicine
    Sally W. Schwarz
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 20N;

Editor's Page

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    Molecular Imaging and Therapy with a Purpose: A Renaissance of Nuclear Medicine
    Johannes Czernin
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 21A-22A;

Issues and Controversies

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    Subjecting Radiologic Imaging to the Linear No-Threshold Hypothesis: A Non Sequitur of Non-Trivial Proportion
    Jeffry A. Siegel, Charles W. Pennington and Bill Sacks
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 1-6; DOI: https://doi.org/10.2967/jnumed.116.180182

Invited Perspectives

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    The Controversial Linear No-Threshold Model
    Wolfgang Weber and Pat Zanzonico
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 7-8; DOI: https://doi.org/10.2967/jnumed.116.182667
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    From NETTER to PETTER: PSMA-Targeted Radioligand Therapy
    Matthias Eiber and Ken Herrmann
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 9-10; DOI: https://doi.org/10.2967/jnumed.116.184994

Commentary

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    SNMMI Comment on the 2016 Society of Surgical Oncology “Choosing Wisely” Recommendation on the Use of PET/CT in Colorectal Cancer
    Katherine Zukotynski, Hossein Jadvar, Thomas Hope, Rathan M. Subramaniam, Katherine Van Loon, Madhulika Varma and Ryan D. Niederkohr; for the PET Center of Excellence
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 11-12; DOI: https://doi.org/10.2967/jnumed.116.182584

Continuing Education

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    Response Assessment Criteria and Their Applications in Lymphoma: Part 2
    Mateen C. Moghbel, Erik Mittra, Andrea Gallamini, Ryan Niederkohr, Delphine L. Chen, Katherine Zukotynski, Helen Nadel and Lale Kostakoglu
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 13-22; DOI: https://doi.org/10.2967/jnumed.116.184242

Focus on Molecular Imaging

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    Metabolic Imaging in Parkinson Disease
    Sanne K. Meles, Laura K. Teune, Bauke M. de Jong, Rudi A. Dierckx and Klaus L. Leenders
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 23-28; DOI: https://doi.org/10.2967/jnumed.116.183152

Oncology

  • Basic Science

    • FEATURED BASIC SCIENCE ARTICLE

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        Dual-Modality Imaging of Prostate Cancer with a Fluorescent and Radiogallium-Labeled Gastrin-Releasing Peptide Receptor Antagonist
        Hanwen Zhang, Pooja Desai, Yusuke Koike, Jacob Houghton, Sean Carlin, Nidhi Tandon, Karim Touijer and Wolfgang A. Weber
        Journal of Nuclear Medicine January 1, 2017, 58 (1) 29-35; DOI: https://doi.org/10.2967/jnumed.116.176099
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      Effect of Carbidopa on 18F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging
      Julien Detour, Alice Pierre, Fréderic Boisson, Guillaume Kreutter, Thomas Lavaux, Izzie Jacques Namer, Laurence Kessler, David Brasse, Patrice Marchand and Alessio Imperiale
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 36-41; DOI: https://doi.org/10.2967/jnumed.116.180588
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      Metabolic Evaluation of Non–Small Cell Lung Cancer Patient–Derived Xenograft Models Using 18F-FDG PET: A Potential Tool for Early Therapy Response
      Silvia Valtorta, Massimo Moro, Giovanna Prisinzano, Giulia Bertolini, Monica Tortoreto, Isabella Raccagni, Ugo Pastorino, Luca Roz, Gabriella Sozzi and Rosa Maria Moresco
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 42-47; DOI: https://doi.org/10.2967/jnumed.116.176404
  • Translational Science

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      Tumor-Absorbed Dose for Non-Hodgkin Lymphoma Patients Treated with the Anti-CD37 Antibody Radionuclide Conjugate 177Lu-Lilotomab Satetraxetan
      Johan Blakkisrud, Ayca Løndalen, Anne C.T. Martinsen, Jostein Dahle, Jon E. Holtedahl, Tore Bach-Gansmo, Harald Holte, Arne Kolstad and Caroline Stokke
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 48-54; DOI: https://doi.org/10.2967/jnumed.116.173922
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      Red Marrow–Absorbed Dose for Non-Hodgkin Lymphoma Patients Treated with 177Lu-Lilotomab Satetraxetan, a Novel Anti-CD37 Antibody–Radionuclide Conjugate
      Johan Blakkisrud, Ayca Løndalen, Jostein Dahle, Simon Turner, Harald Holte, Arne Kolstad and Caroline Stokke
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 55-61; DOI: https://doi.org/10.2967/jnumed.116.180471
  • Clinical Investigation

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      18F-FDG PET for Measurement of Response and Prediction of Outcome to Relapsed or Refractory Mantle Cell Lymphoma Therapy with Bendamustine–Rituximab
      Dominick Lamonica, Daniel A. Graf, Mihaela C. Munteanu and Myron S. Czuczman
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 62-68; DOI: https://doi.org/10.2967/jnumed.116.173542
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      Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma
      Jacob H. Rasmussen, Martin Nørgaard, Adam E. Hansen, Ivan R. Vogelius, Marianne C. Aznar, Helle H. Johannesen, Junia Costa, Astrid M.E. Engberg, Andreas Kjær, Lena Specht and Barbara M. Fischer
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 69-74; DOI: https://doi.org/10.2967/jnumed.116.180091

Theranostics

  • Basic Science

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      Theranostic Perspectives in Prostate Cancer with the Gastrin-Releasing Peptide Receptor Antagonist NeoBOMB1: Preclinical and First Clinical Results
      Berthold A. Nock, Aikaterini Kaloudi, Emmanouil Lymperis, Athina Giarika, Harshad R. Kulkarni, Ingo Klette, Aviral Singh, Eric P. Krenning, Marion de Jong, Theodosia Maina and Richard P. Baum
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 75-80; DOI: https://doi.org/10.2967/jnumed.116.178889
  • Translational Science

    • FEATURED TRANSLATIONAL SCIENCE ARTICLE

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        68Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience
        Thomas A. Hope, Charles Truillet, Eric C. Ehman, Ali Afshar-Oromieh, Rahul Aggarwal, Charles J. Ryan, Peter R. Carroll, Eric J. Small and Michael J. Evans
        Journal of Nuclear Medicine January 1, 2017, 58 (1) 81-84; DOI: https://doi.org/10.2967/jnumed.116.181800
  • Clinical Investigation

    • FEATURED ARTICLE OF THE MONTH

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        German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients
        Kambiz Rahbar, Hojjat Ahmadzadehfar, Clemens Kratochwil, Uwe Haberkorn, Michael Schäfers, Markus Essler, Richard P. Baum, Harshad R. Kulkarni, Matthias Schmidt, Alexander Drzezga, Peter Bartenstein, Andreas Pfestroff, Markus Luster, Ulf Lützen, Marlies Marx, Vikas Prasad, Winfried Brenner, Alexander Heinzel, Felix M. Mottaghy, Juri Ruf, Philipp Tobias Meyer, Martin Heuschkel, Maria Eveslage, Martin Bögemann, Wolfgang Peter Fendler and Bernd Joachim Krause
        Journal of Nuclear Medicine January 1, 2017, 58 (1) 85-90; DOI: https://doi.org/10.2967/jnumed.116.183194
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      Comparison of the Impact of 68Ga-DOTATATE and 18F-FDG PET/CT on Clinical Management in Patients with Neuroendocrine Tumors
      Emmanouil Panagiotidis, Alshaima Alshammari, Sofia Michopoulou, Evangelia Skoura, Keval Naik, Emmanouil Maragkoudakis, Mullan Mohmaduvesh, Mohammed Al-Harbi, Maria Belda, Martyn E. Caplin, Christos Toumpanakis and Jamshed Bomanji
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 91-96; DOI: https://doi.org/10.2967/jnumed.116.178095
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      Diabetes Mellitus and Its Effects on All-Cause Mortality After Radiopeptide Therapy for Neuroendocrine Tumors
      Maria Umlauft, Piotr Radojewski, Petar-Marko Spanjol, Rebecca Dumont, Nicolas Marincek, Attila Kollar, Philippe Brunner, Jan Beyersmann, Jan Müller-Brand, Helmut R. Maecke, Markus Laimer and Martin A. Walter
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 97-102; DOI: https://doi.org/10.2967/jnumed.116.180687

Cardiology

  • Basic Science

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      Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow
      Jennifer M. Renaud, Kathy Yip, Jean Guimond, Mikaël Trottier, Philippe Pibarot, Eric Turcotte, Conor Maguire, Lucille Lalonde, Karen Gulenchyn, Troy Farncombe, Gerald Wisenberg, Jonathan Moody, Benjamin Lee, Steven C. Port, Timothy G. Turkington, Rob S. Beanlands and Robert A. deKemp
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 103-109; DOI: https://doi.org/10.2967/jnumed.116.174565

Neurology

  • Basic Science

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      What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2
      Gil Leurquin-Sterk, Sofie Celen, Koen Van Laere, Michel Koole, Guy Bormans, Xavier Langlois, Anne Van Hecken, Paula te Riele, Jesús Alcázar, Alfons Verbruggen, Jan de Hoon, Jose-Ignacio Andrés and Mark E. Schmidt
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 110-116; DOI: https://doi.org/10.2967/jnumed.116.176628
  • Translational Science

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      Strategies to Inhibit ABCB1- and ABCG2-Mediated Efflux Transport of Erlotinib at the Blood–Brain Barrier: A PET Study on Nonhuman Primates
      Nicolas Tournier, Sebastien Goutal, Sylvain Auvity, Alexander Traxl, Severin Mairinger, Thomas Wanek, Ourkia-Badia Helal, Irène Buvat, Michael Soussan, Fabien Caillé and Oliver Langer
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 117-122; DOI: https://doi.org/10.2967/jnumed.116.178665
  • Clinical Investigation

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      123I-Iodobenzovesamicol SPECT Imaging of Cholinergic Systems in Dementia with Lewy Bodies
      Joachim Mazère, Frédéric Lamare, Michele Allard, Philippe Fernandez and Willy Mayo
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 123-128; DOI: https://doi.org/10.2967/jnumed.116.176180
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      Epileptic Activity Increases Cerebral Amino Acid Transport Assessed by 18F-Fluoroethyl-l-Tyrosine Amino Acid PET: A Potential Brain Tumor Mimic
      Markus Hutterer, Yvonne Ebner, Markus J. Riemenschneider, Antje Willuweit, Mark McCoy, Barbara Egger, Michael Schröder, Christina Wendl, Dirk Hellwig, Jirka Grosse, Karin Menhart, Martin Proescholdt, Brita Fritsch, Horst Urbach, Guenther Stockhammer, Ulrich Roelcke, Norbert Galldiks, Philipp T. Meyer, Karl-Josef Langen, Peter Hau and Eugen Trinka
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 129-137; DOI: https://doi.org/10.2967/jnumed.116.176610

Inflammation/Infectious Disease

  • Basic Science

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      Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling
      Reza Golestani, Mahmoud Razavian, Yunpeng Ye, Jiasheng Zhang, Jae-Joon Jung, Jakub Toczek, Kiran Gona, Hye-Yeong Kim, Jack A. Elias, Chun Geun Lee, Robert J. Homer and Mehran M. Sadeghi
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 138-143; DOI: https://doi.org/10.2967/jnumed.116.176198
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      A Systematic Approach for Developing Bacteria-Specific Imaging Tracers
      Alvaro A. Ordonez, Edward A. Weinstein, Lauren E. Bambarger, Vikram Saini, Yong S. Chang, Vincent P. DeMarco, Mariah H. Klunk, Michael E. Urbanowski, Kimberly L. Moulton, Allison M. Murawski, Supriya Pokkali, Alvin S. Kalinda and Sanjay K. Jain
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 144-150; DOI: https://doi.org/10.2967/jnumed.116.181792
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      Liposomal Treatment of Experimental Arthritis Can Be Monitored Noninvasively with a Radiolabeled Anti–Fibroblast Activation Protein Antibody
      Tessa van der Geest, Peter Laverman, Danny Gerrits, Birgitte Walgreen, Monique M. Helsen, Christian Klein, Tapan K. Nayak, Gert Storm, Josbert M. Metselaar, Marije I. Koenders and Otto C. Boerman
      Journal of Nuclear Medicine January 1, 2017, 58 (1) 151-155; DOI: https://doi.org/10.2967/jnumed.116.177931

Novel Imaging Probes

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    18F-Fluorosulfate for PET Imaging of the Sodium–Iodide Symporter: Synthesis and Biologic Evaluation In Vitro and In Vivo
    Alex Khoshnevisan, Krisanat Chuamsaamarkkee, Mehdi Boudjemeline, Alex Jackson, Gareth E. Smith, Antony D. Gee, Gilbert O. Fruhwirth and Philip J. Blower
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 156-161; DOI: https://doi.org/10.2967/jnumed.116.177519
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    Preclinical Pharmacokinetics and Biodistribution Studies of 89Zr-Labeled Pembrolizumab
    Christopher G. England, Emily B. Ehlerding, Reinier Hernandez, Brian T. Rekoske, Stephen A. Graves, Haiyan Sun, Glenn Liu, Douglas G. McNeel, Todd E. Barnhart and Weibo Cai
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 162-168; DOI: https://doi.org/10.2967/jnumed.116.177857

Physics/Instrumentation

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    In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography
    Zhenhua Hu, Mingxuan Zhao, Yawei Qu, Xiaojun Zhang, Mingru Zhang, Muhan Liu, Hongbo Guo, Zeyu Zhang, Jing Wang, Weidong Yang and Jie Tian
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 169-174; DOI: https://doi.org/10.2967/jnumed.116.180596
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    Cerenkov Luminescence Imaging as a Modality to Evaluate Antibody-Based PET Radiotracers
    Jimson W. D’Souza, Harvey Hensley, Mohan Doss, Charles Beigarten, Michael Torgov, Tove Olafsen, Jian Q. Yu and Matthew K. Robinson
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 175-180; DOI: https://doi.org/10.2967/jnumed.116.178780

Book Reviews

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    Brain Tumor Imaging
    Franklin Wong
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 181; DOI: https://doi.org/10.2967/jnumed.116.186957

Letters to the Editor

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    The Ongoing Misperception That Labeled Leukocyte Imaging Is Superior to 18F-FDG PET for Diagnosing Prosthetic Joint Infection
    Thomas C. Kwee, Sandip Basu and Abass Alavi
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 182; DOI: https://doi.org/10.2967/jnumed.116.181461
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    Reply: The Ongoing Misperception That Labeled Leukocyte Imaging Is Superior to 18F-FDG PET for Diagnosing Prosthetic Joint Infection
    Christopher J. Palestro
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 182-183; DOI: https://doi.org/10.2967/jnumed.116.181669
  • You have access
    PET-Guided Stereotactic Irradiation of Prostate Cancer Lymph Node Metastases
    Peter de Boer, Anna H.M. Piet, Daniela E. Oprea-Lager, Ben J. Slotman and Max R. Dahele
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 183-184; DOI: https://doi.org/10.2967/jnumed.116.181149
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    68Ga-DOTATATE PET/CT Versus MRI: Why the Comparison of 68Ga-DOTATATE PET/CT to an Appropriate MRI Protocol Is Essential
    Guillaume Gravel, Anne-Paule Gimenez-Roqueplo and Philippe Halimi
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 184-185; DOI: https://doi.org/10.2967/jnumed.116.179960
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    Reply: 68Ga-DOTATATE PET/CT Versus MRI: Why the Comparison of 68Ga-DOTATATE PET/CT to an Appropriate MRI Protocol Is Essential
    David Taïeb, Nicholas J. Patronas and Karel Pacak
    Journal of Nuclear Medicine January 1, 2017, 58 (1) 185; DOI: https://doi.org/10.2967/jnumed.116.180109
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In this issue

Journal of Nuclear Medicine: 58 (1)
Journal of Nuclear Medicine
Vol. 58, Issue 1
January 1, 2017
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author

Issue highlights

  • German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients
  • Dual-Modality Imaging of Prostate Cancer with a Fluorescent and Radiogallium-Labeled Gastrin-Releasing Peptide Receptor Antagonist
  • 68Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience
  • Subjecting Radiologic Imaging to the Linear No-Threshold Hypothesis: A Non Sequitur of Non-Trivial Proportion
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  • Oncology
    • Basic Science
      • FEATURED BASIC SCIENCE ARTICLE
    • Translational Science
    • Clinical Investigation
  • Theranostics
    • Basic Science
    • Translational Science
      • FEATURED TRANSLATIONAL SCIENCE ARTICLE
    • Clinical Investigation
      • FEATURED ARTICLE OF THE MONTH
  • Cardiology
    • Basic Science
  • Neurology
    • Basic Science
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  • Long-Term Follow-up and Outcomes of Retreatment in an Expanded 50-Patient Single-Center Phase II Prospective Trial of 177Lu-PSMA-617 Theranostics in Metastatic Castration-Resistant Prostate Cancer
  • First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
  • Impact of 68Ga-PSMA-11 PET/CT on Staging and Management of Prostate Cancer Patients in Various Clinical Settings: A Prospective Single-Center Study
  • Tau PET imaging with 18F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study
  • Radiation Dosimetry in 177Lu-PSMA-617 Therapy Using a Single Posttreatment SPECT/CT Scan: A Novel Methodology to Generate Time- and Tissue-Specific Dose Factors
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