Abstract
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Objectives To analyze the PET/CT imaging characteristics of IgG4 related diseases (IgG4 related diseases, IgG4RD) and investigate the function of 18F-FDG PET/CT in diagnosing of IgG4RD and whole-body evaluation.
Methods Whole-body 18F-FDG PET/CT findings in 14 patients (male 12, female 2, age from 43 to 75, the median age of 59 years old) with clinical conformed IgG4RD were reviewed retrospectively. Organs' morphology changes, density alter and 18F-FDG metabolism was observed.
Results All of 14 cases had a high level of serum IgG4, 970.14 + / - 950.70 mg/dl (136 ~ 3690 mg/dl). 18F-FDG PET/CT imaging show there were multiple organ involvement in IgG4RD, 12 cases (85.7%) with pancreas involvement, characterized by diffuse or segmental enlargement of the pancreas with increased 18F-FDG uptake; 9 cases (62.3%) with salivary gland involvement, characterized by unilateral or bilateral salivary glands swelling with increased 18F-FDG uptake; 6 cases (42.9%) had bile duct system involved, characterized by mild expansion of bile ducts with mild thickening wall. Along the bile duct 18F-FDG uptake was increased; 7 in 12 male patients (58.3%) had prostatic involved, characterized by unilateral or bilateral lobe with increased 18F-FDG uptake; Other organs were involved including thyroid (5 cases), lung (4 cases), intestinal (4 cases), artery (2 cases) and kidney (1 case).
Conclusions IgG4RD is a systemic disease. 18F-FDG PET/CT shows well the changes and metabolic characteristics of organs which are involved in IgG4RD. It plays a distinct role in diagnosis of IgG4RD and whole-body evaluation.
Research Support This study is funded by National Natural Science Foundation of China ((81170435,81471714)); China Postdoctoral Science Foundation (20100480545);The International Cooperationprojects ofShanghai Science and Technology Committee (10410708800).