Abstract
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Objectives To investigate the variation of SUV values in 99mTc-MDP bone scans using SUV SPECT hybrid reconstruction based quantitative methods.
Methods 430 patients (mean age 63.07) were enrolled and were divided into three groups: Group1 was 298 without vertebral disease,group2 was 51 with degenerative changes, group3 was 81 with bone metastases.To generate SUV-calibrated images, the raw SPECT data was reconstructed using the software ‘SUV-SPECT’ . Corrections were applied for CT attenuation, Monte Carlo-modeled scatter correction, resolution recovery, scaling for injected dose and radioactive decay. The units of counts-per-voxel were scaled to activity per unit volume (Bq/cc) based on previously performed phantom calibration work to allow for SUV measurements. The reconstructed images were analyzed using a constrained threshold-based volume of interest approach to automatically calculate the uptake in the bony structures. SUVmax by body weight was recorded in the derived volume.All the values were measured twice to verify consistency.
Results The mean SUVmax for group1 was 7.09±1.6(cervical vertebra),6.54±1.19(thoracic vertebra),7.79±1.41(lumbar vertebra) and7.93±2.91(pelvis).For group 2 the mean SUVmax was 11.46 ± 4.09. For group 3 was 25.23±1.97 (cervical vertebra),40.73±32.66(thoracic vertebra), 52.43±18.96(lumbar vertebra) and 53.24±38.79(pelvis). There were significant differences between group 3 and 1 (P<0.01). The mean SUVmax between the degenerative and the normal (groups 1 & 2) had no statistical difference. The repeated results were consistent.
Conclusions This method is accurate, easy-to-use and robust, providing absolute quantification in SPECT/CT, which promises to be widely used in primary diagnosis and evaluation of therapy response.Furthermore, Multi-center data planned to be acquired to build up SUV variation in bone scan through cloud-based solutions.