Abstract
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Objectives The purpose of this study was to assess the results of dementia screening with the analysis of three-dimensional stereotactic surface projection (3D-SSP) of FDG-PET images for over 1,000 healthy subjects without subjective symptoms.
Methods We included 1,340 healthy subjects (561 females: 63.6±9.1 yrs.: 779 males: 64.0±9.0 yrs.) who received whole-body cancer screening with optional dementia screening. All subjects underwent medical questionnaire, mini mental state examination (MMSE), whole-body imaging examinations using CT, MR, US and FDG-PET. Age and gender match database was generated from 6000 healthy subjects who received whole-body cancer screening and used for the analysis of 3D-SSP of FDG-PET images. Our original system for computer-aided diagnosis of Alzheimer’s disease (AD) was also used to support interpretation of 3D-SSP images.
Results A hundred and thirty-one subjects (about 10%) showed slight to moderate abnormal findings suggesting possible AD, mild cognitive impairment MCI), fronto-temporal dementia and semantic dementia. There was no gender difference in a rate of abnormality. Age dependent increase of abnormal findings was observed and the rate of abnormality was 7% at ages under 65 year-old and 12 % at ages over 65 year-old. Several subjects referred to hospital received diagnosis of MCI and were followed periodically.
Conclusions Our preliminary results of dementia screening showed that about 10% of population with a mean age of 64 year-old without subjective symptoms had abnormal findings suggesting a possibility to develop dementias in the near future. Prospective follow-up is essential for these people to confirm the utility of dementia screening using 3D-SSP analysis of FDG-PET images.