Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Follow JNM on Twitter
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Subscribe to our RSS feeds
Meeting ReportMolecular Targeting Probes - Radioactive & Nonradioactive

Integrated microfluidic lab-on-a-chip systems for 18F radiotracer synthesis, purification and quality control

Steve Archibald, Nicole Pamme, Nathan Brown and Mark Tarn
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 167;
Steve Archibald
1PET Research Centre, University of Hull, Hull, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicole Pamme
1PET Research Centre, University of Hull, Hull, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nathan Brown
1PET Research Centre, University of Hull, Hull, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Tarn
1PET Research Centre, University of Hull, Hull, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

167

Objectives Dose-on-demand radiotracer production, whereby a single dose is generated using a compact synthesis unit with radioisotope from a mini-cyclotron or external supply is an interesting prospect for widening the availabilty of radiotracers. We aim to produce modules for lab-on-a-chip device design that can be used for isotope processing, synthesis and some routine quality control tests on a microfluidic scale.

Methods Modules for electrode trapping and release of [18F]fluoride, synthesis of [18F]FDG and purification were produced as prototypes using bespoke manufactured microfluidic glass chips with etched channels. Monolithic separation columns were made of a suitable size from silica and the functionality by chemical modification for the different purification and separation applications.Synthesis to validate the [18F]fluoride feed was carried out in a heated capillary loop. Spectroscopic quality control tests were developed using a simple on-chip absorbance-based system for performing QC tests rapidly (few min) with small volumes (<2 μL).

Results A process for highly efficient trap and release of [18F]fluoride from a low volume (< 200 μl) of aqueous solution allows trap and release into acetonitrile with an efficiency of up to 95% in both steps. Synthesis and purification using silica monolith columns designed for incoporation into microfluidic devices allowed isolation of pure product in good radiochemical yield (>80%). V-shaped plots were used to validate pH using absoprtion spectroscopy and solvent impurity using raman spectroscopy.

Conclusions Modules have been designed and tested for the synthesis of [18F]FDG. An efficient process for transfer of the [18F]fluoride into acetonitrile via electrode trapping allows synthesis of the [18F]FDG with high efficiency at low volumes was validated. Spearation modules using small (1-2 cm length) bespoke mopnolithic silica columns were used in the separations and some of the quality control tests were shown to be effective using both real samples and standards.

Research Support The authors thank the Daisy Appeal (grant no. DAhul0211) and the University of Hull (HEIF) for financial support. We would like to thank Dr Assem Allam for his generous support of this project.

Previous
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 56, Issue supplement 3
May 1, 2015
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Integrated microfluidic lab-on-a-chip systems for 18F radiotracer synthesis, purification and quality control
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Integrated microfluidic lab-on-a-chip systems for 18F radiotracer synthesis, purification and quality control
Steve Archibald, Nicole Pamme, Nathan Brown, Mark Tarn
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 167;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Integrated microfluidic lab-on-a-chip systems for 18F radiotracer synthesis, purification and quality control
Steve Archibald, Nicole Pamme, Nathan Brown, Mark Tarn
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 167;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Molecular Targeting Probes - Radioactive & Nonradioactive

  • A general 11C-carboxylation approach mediated by fluoride-desilylation of organosilanes
  • Relationships between tau, atrophy, regional brain activity and connectivity in Alzheimer's disease: a PET/MRI multimodal study
  • Gray matter structural networks related to 18F-THK5351 retention in cognitively normal older adults and early Alzheimer’s disease patients
Show more Molecular Targeting Probes - Radioactive & Nonradioactive

Automation and Process Development

  • Design and Prototype of an Automated "In-loop" [11C]CO2-Fixation Apparatus
  • Autmoated radiosynthesis of 18F-THK-5351 using the Sofie ELIXYS
  • Production of Curie quantities of 68Ga with a medical cyclotron via the 68Zn(p,n)68Ga reaction
Show more Automation and Process Development

Similar Articles

SNMMI

© 2022 Journal of Nuclear Medicine

Powered by HighWire