Abstract
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Objectives To compare the efficiency of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) and Contrast-Enhanced Computed Tomography (CECT) in lymph node staging for patients with lung cancer.
Methods Eighty-two patients with lung cancer underwent both PET/CT and chest contrast enhanced computed tomography (CECT) examination preoperatively. The efficacies in diagnosing lung cancer and regional lymph nodes staging were compared with pathologic results as the gold standard.
Results A total of 564 mediastinal lymph nodes were resected in 82 patients and 78 (13.8%) of the lymph nodes were confirmed with metastases by pathology.PET/CT is superior to CECT in its sensitivity, specificity, accuracy, and positive and predicting value in diagnosing regional lymph node metastasis (all P<0.05). Overall accuracies of PET/CT and CECT in staging lymph node with pathological was 87.8% (72/82) and 70.7% (50/82), respectively. (p<0.05) The accuracies in staging N0, N1, N2 was 89.3% (25/28), 83.3% (20/24), 90.0% (27/30) of PET/CT versus 85.7% (24/28), 50.0% (12/24), 73.3% (22/30) in CECT.
Conclusions 18F-FDG PET/CT is more accurate in evaluating lymph node metastasis and staging in patients with lung cancer, compared to CECT. It is recommended that appropriate combinative application of 18F-FDG PET/CT and CECT be adopted to get the most accurate clinical data in patients with metastatic lung cancer.
Research Support This study is funded by National Natural Science Foundation of China ((81170435,81471714)); China Postdoctoral Science Foundation (20100480545);The International Cooperationprojects ofShanghai Science and Technology Committee (10410708800).