Abstract
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Objectives To assess the correlation between the level of 99TcmN-NOET uptake by pulmonary nodules with long-term prognostic value in patients with lung cancer.
Methods Fifty-one patients (37 men, mean age 57 ± 9 years) with primary malignancy of lung underwent CT, early and delay 99TcmN-NOET dual-phase SPECT before operated. All patients completed clinical follow-up regarding poor prognosis (recurrence and metastasis, death) for a mean period of 84 ±6 months.
Results Poor prognosis rates were analysed in subgroups defined according to the presence of the value of early T/N ratio (ER),delayed T/N ratio (DR) and the retention index (RI%).During the follow-up, 9 deaths were recorded, 13 of lymph node metastases, 7 of other soft tissues metastases, 7 of bone metastases. The high risk for poor prognosis was associated with the presence of accumulate NOET of all analysed end points: early 99TcmN-NOET SPECT by lung nodules (HR = 2.76,P =0.01), delayed 99TcmN-NOET SPECT(HR =2.66, P = 0.001), the retention index(HR =2.55,P = 0·001), tumor diameter(HR =1.66, P = 0.06), liquefaction necrosis(HR =1.58, P =0.08).
Conclusions The more accumulate of NOET was associated with poor prognosis in patients of lung cancer. In long-term follow-up, 99TcmN-NOET SPECT proved highly predictive of poor prognosis in patients with lung cancer.
Research Support The fund of basic research project of Shanxi Province(2012021030-2) The fund of science and technology innovation projects of Shanxi province colleges and universities(20141101) The fund of youth innovation of Shanxi medical university(01201415)