Abstract
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Objectives To evaluated the utility of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scan in the diagnosis of cutaneous Extranodal natural killer/ T-cell lymphoma, Nasal Type (CNKTCL).
Methods A total of 39 patients with extranodal natural killer (NK)/T-cell lymphoma, nasal-type (ENKTL) who had single skin symptom were enrolled between May 2009 and November 2013.They all had undergone both MR imaging and 18F-FDG PET/CT examinations before the skin lesion diagnosed. Biopsy was used as the gold standard for diagnosis.
Results Of all the 39 eligible patients, 30 malignancy skin lesions were confirmed by histopathology. 18F-FDG PET/CT detected 28 lesions, while MR detected only 21 lesions. 18F-FDG PET/CT was superior to MR in 19 lesions without anatomic region-based abnormality [13⁄19 lesions (68.4%) vs. 7⁄19 lesions (36.8%), respectively; P= 0.013]. Univariate analysis showed that focal anatomical abnormality, pre-chemotherapy and EB virus infection were significant predictors of higher SUVmax, although only focal anatomical abnormality remained an independent determinant of higher SUVmax on multivariate analysis (p=0.027).
Conclusions Our findings indicate that 18F-FDG PET/CT has an advantage over MR in the detection of CNKTCL, especially for the cutaneous lesions without anatomic region-based abnormality.