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Meeting ReportOncology: Basic, Translational & Therapy

SUVmax of Normal Tissues in Pediatric and Adult Patients on FDG PET/MR

Tiffany Sills, Timothy R Gershon, Bhisham Chera, Weili Lin and Amir Khandani
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 1270;
Tiffany Sills
1Radiology, University of North Carolina, Chapel Hill, NC
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Timothy R Gershon
1Radiology, University of North Carolina, Chapel Hill, NC
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Bhisham Chera
1Radiology, University of North Carolina, Chapel Hill, NC
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Weili Lin
1Radiology, University of North Carolina, Chapel Hill, NC
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Amir Khandani
1Radiology, University of North Carolina, Chapel Hill, NC
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Abstract

1270

Objectives To measure SUVmax of various normal tissues in pediatric and adult patients and compare them to each other.

Methods A total of 22 (9 pediatric [<18 y/o] and 13 adult) patients with a pre-therapy FDG PET/MR scan (Biograph mMR) were included in this retrospective study. SUVmax in aortic arch, liver (periphery and central), subcutaneous fat (right and left flanks and chest walls) and lungs (right and left) was calculated by placing a 3-D ROI. Data were analyzed by 2-tailed Student’s t-test and Pearson’s correlation coefficient (R).

Results The average age was 14.3 + 2.7 years in pediatric and 54.6 + 10.7 years in adult patients. The average uptake time was 71 + 4.8 minutes in the pediatric and 67 + 3.8 minutes in the adult group (P=0.055). The SUVmax of various tissues are given in the attached table. There was a statistically significant difference in SUVmax between the pediatric and adult group in the aorta, liver and lungs (P<0.005 for all). Age and SUVmax correlated well across all these tissues (R > +0.6; P<0.01). There was no statistically significant difference in SUVmax of the subcutaneous fat between the pediatric and adult group, and this correlated only minimally with age (R < +0.3 across both tissues). There was no statistically significant difference in SUVmax measured in various locations (e.g. central and periphery of the liver) of the same tissue.

Conclusions The SUVmax of various normal tissues is lower than the corresponding known values on PET/CT, which goes along with the described generally lower SUV on PET/MR comparted to PET/CT. However, SUVmax is reproducible in various location of the same tissue, which indicates the robustness of the measurements. Finally, there is an age-dependent increase in SUVmax on PET/MR in aorta, liver and lungs from pediatric to adult patients. These preliminary data will help to establish normal tissue reference standards on FDG PET/MR but need to be confirmed in larger studies.

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Journal of Nuclear Medicine
Vol. 56, Issue supplement 3
May 1, 2015
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SUVmax of Normal Tissues in Pediatric and Adult Patients on FDG PET/MR
Tiffany Sills, Timothy R Gershon, Bhisham Chera, Weili Lin, Amir Khandani
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 1270;

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SUVmax of Normal Tissues in Pediatric and Adult Patients on FDG PET/MR
Tiffany Sills, Timothy R Gershon, Bhisham Chera, Weili Lin, Amir Khandani
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 1270;
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