Dose Optimization of the Administered Activity in Pediatric Bone Scintigraphy: Validation of the North American Consensus Guidelines

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FIGURE 1.
Percentage diagnostic by imaging protocol (masked analysis).
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FIGURE 2.
Percentage acceptable for daily clinical use (unmasked analysis).
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FIGURE 3.
Institutional (A) and NACG (B) images of a patient for whom, on unmasked analysis, the institutional images were subjectively deemed acceptable for daily clinical use but the NACG images were not. Abnormal uptake in the abdominal mass and multiple bone metastases is evident on both sets of images.

TABLE 1

Administered Activities and Effective Doses for 3 Dosing Schedules

Weight (kg)	MBq	mSv	Effective dose reduction vs. institutional
Institutional
5	148	7.8
10	207	5.6
20	370	5.1
30	444	5.0
40	570	5.5
50	666	5.4
60	696	4.7
70	740	4.2
NACG
5	46	2.5	−68%
10	93	2.5	−55%
20	185	2.6	−49%
30	278	3.1	−38%
40	270	3.6	−35%
50	463	3.8	−30%
60	555	3.7	−21%
70	648	3.7	−12%
EANM Dosage Card
6	60	3.2	−59%
10	95	2.6	−54%
20	170	2.4	−53%
30	240	2.7	−46%
40	310	3.0	−45%
50	375	3.0	−44%
60	445	3.0	−36%
68	490	2.8	−33%

EANM activities include patient weights of 6 and 68 kg rather than 5 and 70 kg, based on design of EANM Dosage Card.

TABLE 2

Patient Demographics and Indications for Imaging