Article Figures & Data
Figures
- FIGURE 1.
(A) Examples of standardized uptake value curves for all 27 VOIs of 11C-yohimbine presented for subject 5 (abscissa is mid-frame time [minutes] and ordinate is standardized uptake value of radioactivity in VOIs). Blue line shows corpus callosum, which was used as reference region for calculation of binding potentials (BPND). (B) Radioactivity in plasma, expressed as fraction of radioactivity in VOIs, is shown on ordinate, and abscissa represents time (minutes).
- FIGURE 2.
Fractions of unchanged 11C-yohimbine were interpolated to match time points of tissue time–activity curves, presented here for all 6 subjects. Ordinate represents intact 11C-yohimbine, and abscissa shows time (minutes).
- FIGURE 3.
Six linearized solutions were used to derive linear regression estimates of kinetic parameters, using metabolite-corrected plasma curves as input function: plot N1 (A), plot N2 (B), plot P1 (C), plot P2 (D), plot P3 (E), plot P4 (F). Blue lines represent corpus callosum.
- FIGURE 4.
Average parametric images of voxelwise
estimates in 5 of 6 subjects, estimated with P2 plot (Logan plot). Color bar gives estimates of in units of mL cm−3.
Tables
Subject MBq Yohimbine (nmol) CYP2D6 1 641 30.3 1 × 2 (F) 2 441 4.6 4 × 1 (M) 3 635 7 1 × 4 (M) 4 715 21.4 4 × 4 (N) 5 507 11.2 2 × 5 (M) 6 169 11 2 × 2 (F) F, M, and N = fast, moderate, and nonmetabolizers, respectively, of 11C-yohimbine.
VOI VT (mL/cm3) K1 (mL/cm3/min) (min−1)Binding potential Amygdala, L 0.55 ± 0.11 0.014 ± 0.002 0.026 ± 0.002 0.22 ± 0.12 Amygdala, R 0.55 ± 0.10 0.014 ± 0.002 0.025 ± 0.001 0.23 ± 0.07 Caudate nucleus, L 0.55 ± 0.10 0.016 ± 0.003 0.029 ± 0.002 0.24 ± 0.13 Caudate nucleus, R 0.56 ± 0.12 0.016 ± 0.003 0.028 ± 0.002 0.23 ± 0.11 Cerebellum, L 0.57 ± 0.10 0.019 ± 0.003 0.032 ± 0.002 0.28 ± 0.11 Cerebellum, R 0.59 ± 0.11 0.020 ± 0.003 0.032 ± 0.002 0.32 ± 0.11 Corpus callosum 0.46 ± 0.09 0.009 ± 0.001 0.019 ± 0.003 — Frontal lobe, L 0.80 ± 0.16 0.020 ± 0.003 0.023 ± 0.001 0.77 ± 0.14 Frontal lobe, R 0.82 ± 0.16 0.020 ± 0.003 0.023 ± 0.001 0.81 ± 0.13 Gyrus cinguli, L 0.80 ± 0.16 0.020 ± 0.003 0.025 ± 0.001 0.77 ± 0.14 Gyrus cinguli, R 0.80 ± 0.15 0.020 ± 0.003 0.024 ± 0.001 0.77 ± 0.14 Hippocampus, L 0.77 ± 0.13 0.016 ± 0.003 0.021 ± 0.003 0.73 ± 0.14 Hippocampus, R 0.82 ± 0.16 0.014 ± 0.002 0.018 ± 0.003 0.82 ± 0.21 Insula, L 0.72 ± 0.14 0.017 ± 0.003 0.023 ± 0.001 0.61 ± 0.15 Insula, R 0.73 ± 0.13 0.017 ± 0.003 0.023 ± 0.001 0.62 ± 0.12 Occipital lobe, L 0.78 ± 0.15 0.020 ± 0.003 0.024 ± 0.001 0.73 ± 0.14 Occipital lobe, R 0.82 ± 0.17 0.020 ± 0.004 0.024 ± 0.001 0.80 ± 0.12 Parietal lobe, L 0.78 ± 0.15 0.019 ± 0.003 0.023 ± 0.001 0.72 ± 0.13 Parietal lobe, R 0.79 ± 0.16 0.019 ± 0.003 0.023 ± 0.001 0.75 ± 0.11 Putamen, L 0.62 ± 0.12 0.021 ± 0.004 0.032 ± 0.002 0.40 ± 0.15 Putamen, R 0.60 ± 0.12 0.020 ± 0.004 0.033 ± 0.002 0.33 ± 0.12 Temporal lobe, L 0.75 ± 0.13 0.017 ± 0.003 0.022 ± 0.001 0.67 ± 0.13 Temporal lobe, R 0.75 ± 0.14 0.017 ± 0.003 0.022 ± 0.001 0.66 ± 0.12 Thalamus, L 0.62 ± 0.12 0.018 ± 0.003 0.029 ± 0.002 0.37 ± 0.09 Thalamus, R 0.65 ± 0.10 0.019 ± 0.004 0.027 ± 0.002 0.46 ± 0.11 White matter, L 0.59 ± 0.11 0.012 ± 0.002 0.020 ± 0.001 0.30 ± 0.10 White matter, R 0.59 ± 0.12 0.012 ± 0.002 0.019 ± 0.001 0.30 ± 0.09 Data are mean ± SEM.
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