Abstract
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Objectives In this study, we aimed to explore the prognostic factors in patients who received selective internal radiation therapy for hepatocellular cancer.
Methods We retrospectively evaluated 28 (24Male; 4Female; mean age: 65.4±6.8) hepatocellular cancer patients who received selective internal radiation therapy. Relationship between age, gender, number of liver lesions, size of the largest lesion, absence of 18F-FDG uptake and maximum standardized uptake value and overall survival times were analysed by using Cox proportional hazards regression analysis
Results Treatment has been given to right and both lobes in 22 and 6 patients, respectively. Mean treatment dose was 1.5±0.2GBq. Number of liver lesions were one, less than 5 and multipl in 16, 5 and 7 patients and mean size of the largest lesions was 41.5mm (min-max: 15-160mm). While 18F-FDG uptake was seen in 25 patients, liver lesions were hipometabolic in 4 patients. Mean SUVmax of liver lesions was calculated as 5.3±0.3. 19 patients were died during mean 17.8±14.8 monhts follow-up period. Median survival time was computed as 18±5 months (95%CI: 8.1-27.8). Age (p=0.44) and size of the largest lesion (p=0.29) had significant negative effect on survival according to Cox proportional hazards regression analysis. One unit increase in age and size 0.8 and 0.9 fold increase in hazard, at any time.
Conclusions Age and size of the largest liver lesion have negative significant effect on survival of hepatocellular cancer patients who received selective internal radiation therapy.