Article Figures & Data
Tables
- TABLE 1
Patient Characteristics and Hepatic Removal Kinetics of Galactose and LC for 18F-FDGal in Patients with Liver Disease
Patient no. Sex Age (y) Body weight (kg) Etiology Vmax (mmol/min) Km (mmol/L of blood) Vmax/Km (L of blood/min) LC 1 Male 61 70 Alcohol 1.52 ± 0.40 0.81 ± 0.40 1.88 ± 0.33 0.18 ± 0.05 2 Male 66 86 Alcohol 1.56 ± 0.17 0.93 ± 0.19 1.68 ± 0.14 0.23 ± 0.03 3 Female 60 82 Cryptogenic 1.01 ± 0.10 1.00 ± 0.22 1.00 ± 0.13 0.23 ± 0.04 4 Male 57 79 Alcohol + HCV 1.48 ± 0.52 1.41 ± 0.77 1.05 ± 0.25 0.27 ± 0.08 5 Female 71 83 Cryptogenic 2.16 ± 0.27 1.96 ± 0.43 1.10 ± 0.12 0.29 ± 0.05 6 Male 51 93 Alcohol 1.17 ± 0.22 0.48 ± 0.20 2.42 ± 0.39 0.18 ± 0.04 7 Male 62 90 Alcohol 1.19 ± 0.18 0.82 ± 0.26 1.45 ± 0.24 0.22 ± 0.08 8 Male 65 62 Alcohol 0.95 ± 0.11 1.19 ± 0.22 0.79 ± 0.08 0.28 ± 0.03 9 Male 43 70 Alcohol 1.75 ± 0.35 0.80 ± 0.23 2.17 ± 0.16 ND Mean ± SE 1.18 ± 0.06† 0.91 ± 0.08 1.18 ± 0.05‡ 0.24 ± 0.02§ Healthy subjects Mean 2.66 0.95 2.74 0.13 Range 1.81–5.34 0.59–2.17 2.16–3.13 0.10–0.17 ↵† P < 0.01 when compared with healthy subjects.
↵‡ P < 0.001 when compared with healthy subjects.
↵§ P < 0.0001 when compared with healthy subjects.
HCV = hepatitis C virus; ND = intrinsic clearance of 18F-FDGal could not be determined (7); mean ± SE = weighted mean ± SE of weighted mean.
Vmax and Km were calculated according to Equation 2; LC was calculated according to Equation 1. Individual data are given as mean ± SE of estimate. Data from healthy subjects are from Sørensen et al. (3).
Patient no. 
(L blood/min/L of liver) (mmol galactose/min/L of liver)1 0.014 ± 0.002 0.54 ± 0.31 2 0.026 ± 0.001 0.69 ± 0.18 3 0.020 ± 0.001 0.74 ± 0.24 4 0.022 ± 0.001 0.70 ± 0.45 5 0.039 ± 0.003 0.96 ± 0.32 6 0.007 ± 0.002 0.27 ± 0.15 7 0.007 ± 0.001 0.21 ± 0.11 8 0.015 ± 0.001 0.47 ± 0.11 9 0.023 ± 0.002 ND Mean ± SE 0.019 ± 0.001 0.57 ± 0.06† Healthy subjects Mean 0.019 1.41 Range 0.011–0.029 1.10–2.11 ↵† P < 0.0001 when compared with healthy subjects.
- = hepatic systemic clearance of 18F-FDGal determined from 18F-FDGal PET/CT with infusion of galactose; = maximum hepatic removal rate of galactose determined from 18F-FDGal PET/CT according to Equation 4; ND = not determined (LC not available; Table 1); mean ± SE = weighted mean ± SE of weighted mean.
Individual data are given as mean ± SE of estimate. Data from healthy subjects are from Sørensen et al. (3).
