Abstract
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Objectives Skull base invasion(SBI) occurred frequently and is one of poor prognosis signs in patients with Nasopharyngeal Carcinoma(NPC). The purpose of this study is define the value of SBI detected by bone scan to predict the local recurrence of NPC.
Methods There wrere 89 patients (M:F = 63:36, Age range=25-75y/o, Mean=53.7y/0) with pathologically proved NPC and all of these patients had bone scan with skull SPECT before treatment. These patients were followed at clinic for at least 1 year (range= 1-5 years, mean=4.3 years). Local recurrence was defined while positive findings on CT or MRI and proved by pathological finndings.
Results Among 89 patients, there were 32 patients with SBI and 67 patients without SBI. Nine out ot 32 patients with SBI had local recurrence during follow-up, and 3 out of 67 patients without SBI had local recurrence during follow up(p<0.01). The recurrence was noted 3.2 years after treatment in patients with SBI, and 3.9 years in patients without SBI(p<0.01).
Conclusions SBI noted by bone scan is a reliable indicator to predict local recurrence in patients with NPC.