Abstract
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Objectives Various software packages have been developed for gated myocardial perfusion SPECT that use different algorithms for segmenting the left ventricle and calculating left ventricular end-diastolic and systolic volumes (EDV and ESV, respectively) and left ventricular ejection fractions (LVEF). In this study we sought to compare the left ventricular parameters for QGS, 4DM, and MIMcardiac.
Methods SPECT scans for 19 patients (11 males, 9 females; age range, 34-84) were randomly selected retrospectively and processed with QGS, 4DM, and MIMcardiac. EF, EDV, and ESV were recorded and mean values and correlations (CC) between the methods were calculated.
Results LVEF results were significantly different between all methods (p < 0.05) with a mean LVEF for MIMcardiac, QGS, and 4DM of 53% +/- 6%, 60% +/- 9%, and 64% +/- 10% repectively. However, all methods were found to correlate well with CC for MIM vs QGS (0.75), MIM vs 4DM (0.75), and QGS vs 4DM (0.76). EDV and ESV results were also significantly different for all methods except the ESV for QGS vs 4DM (p=0.49). However, volumes for all methods correlated well (CC >0.91). Mean EDV and ESV for MIM, QGS, and 4DM were (119 +/-28ml and 57 +/-18ml), (87 +/- 25ml and 36 +/- 18ml), and (93 +/- 25ml and 35 +/- 18ml) respectively.
Conclusions While the results for QGS, 4DM and MIMcardiac correlated well, the mean LVEF and LV volumes were found to differ significantly between all methods and should not be used interchangeably