Abstract
1822
Objectives To evaluate extra-aortic arterial FDG accumulation in asymptomatic cohorts by sex, and to clarify the association with cardiovascular risk factors (CRF) and coronary artery stenosis (CAS).
Methods A total of 529 individuals who underwent a cancer and CAS screening using FDG-PET/CT and coronary MRA were enrolled.The subjects consisted of 358 men and 171 women (mean:57, range:28-84 yrs).We visually evaluated extra-aortic accumulation in carotid artery (CA) and iliac to femoral artery (IFA), and accumulation pattern was classified to 3 types.Type1 subjects had no extra-aortic accumulation, type2 had accumulation in either CA or IFA, and type3 had accumulation in both CA and IFA. CRF [age, LDL, HDL, and TG concentration, visceral abdominal fat (VAT), HT, diabetes, smoking] and severe CAS (75%≦) of proximal to mid-portion were examined in relation to each accumulation type.
Results Men showed broader extra-aortic arterial accumulation than women. Type3 accumulation (60.3 vs. 36.8%, p < 0.0001) was more commom in men, whereas type2 (34.4 vs. 45.0%, p = 0.02) and type1 (5.3 vs. 18.1%, p < 0.0001) accumulation was more common in women. CRF except for smoking tended to be worse in type3 subjects than the other types. Age, VAT, LDL, and TG (in both sex), HT (in men), HDL (in women) of type 3 subjects were significantly worse than the other types (p < 0.05 - 0.0001).Multivariate logistic regression showed age and VAT (OR = 1.07 and 1.01, p < 0.01 in both) were associated with type3 accumulation in men, and age (OR = 1.06, p < 0.001) was associated in women. CAS was found in 3.9% (10 men and 1 woman) of type3 subjects, but no CAS was found in the other types.
Conclusions Extra-aortic arterial FDG accumulation correlated with CRF.Type3 accumulation was more common in men, and this accumulation was associated with age and/or VAT. Type 3 accumulation was considered to be a risk for severe CAS