Abstract
1405
Objectives To evaluate the accuracy of 18F- fluorodeoxyglucose (FDG)-positron emission tomography (PET) for diagnosis and management of renal tumors.
Methods Between July 2010 and August 2011, 30 patients with suspicious renal tumors detected by conventional imaging underwent FDG PET/CT imaging, 22 patients underwent dual-time imaging. All patients underwent nephrectomy or surgical resection or biopsy of the renal tumor and the final diagnoses were based on histopathology.The impact of FDG PET/CT on disease management was also assessed.
Results Of the 30 patients, 24 patients had renal cell carcinoma(RCC) (19 clear cell RCC, 4 multilocular cystic RCC, 1 papillary RCC), 1 patient had renal neuroendocrine tumor, 3 patients were diagnosed as renal lymphoma, 1 patient was secondary renal tumor, 1 renal tumor was benign, corresponding to renal inflammatory disease. PET showed a sensitivity of 89.66%, specificity of 100%, accuracy of 90%, positive predictive value of 100% and negative predictive value of 25% for renal tumors. PET/CT detected 2 cases with local metastatic lymph node and 5 cases with distant metastatic lesions. In all, the treatment of 8 patients was altered according to PET/CT. The Fuhrman grade of the patients with FDG-positive malignant lesions were higher than that of the patients with FDG-negative lesions(P<0.05). The median size of FDG-positive tumors was greater than that of FDG-negative tumors(P<0.05). In RCC, the change between early and delayed imaging for SUVmax was not statistically significant(P>0.05).
Conclusions PET/CT can accurately detect local and metastatic lesions in patients with renal tumor. Patients with suspicious renal lymphoma or secondary renal tumor should perform PET/CT imaging for accurately staging or detecting the primary tumor