Abstract
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Objectives This study was performed to evaluate the effects of intravenously transplanted rat bone marrow-derived mesenchymal stem cells (rBMSCs) in an acute brain trauma model using serial F-18 FDG PET in rat models.
Methods Trauma models were made in 22 rats by a controlled cortical impact injury device. Twelve rats were treated with intravenously injection of 1.0*106 BMSCs and 10 trauma models without stem cell therapy were control group. Serial F-18 FDG PET images were obtained on 1, 7, 14 and 28 days after trauma. The ratio of FDG uptake on region of interest of trauma lesion to contralateral normal cortex were measured.
Results The mean ratio of FDG uptake on 28 days was significant higher than the ratio of 1 day after stem cell therapy (Wilcoxon rank sum test, p<0.05). There was no significant difference of FDG uptakes between one and 28 days after trauma in control group (p=0.12). The line graph showed increasing trend of serial FDG uptakes after stem cell therapy, while plateau in control group. (Fig. 1).
Conclusions BMSC therapy in trauma models leaded improvement of glucose metabolism and this result might support the therapeutic effect of stem cell in brain trauma injury