Abstract
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Objectives The aim of the study was to evaluate the changes of dopamine transporters(DAT) binding in methamphetamine (MA) users after a two-week or four-week period of abstinence.
Methods Tc-99m-TRODAT-1 SPECT imaging was performed in 5 healthy volunteers and 12 MA abusers. Among the abusers, 12 abusers underwent twice imaging (0, two-week abstinence) and 6 abusers underwent three times (previously used: T1, two-week abstinence: T2, four-week abstinence: T3). Outline the right striatum (RST) and the left striatum (LST) as ROI on the 4 most clearly consecutive transverse slices. Take the occipital region (OC) as the reference area and the specific uptake ratio (SUR) was calculated and. Values of MA abusers were compared with healthy volunteers. the values of T1, T2 and T3 compared with each other. The date analysis use SPSS 15.0.
Results The average SUR of the healthy volunteers is 3.08±0.48, (ranged from 2.59 to 3.82); Among the MA abusers, the average SUR is 2.22±0.22, (ranged from 1.80 to 2.63) in the first time, 2.41±0.24(ranged from 1.90 to 2.77) after two-week abstinence and 2.66±0.22 (ranged from 2.38 to 3.03) after four-week abstinence. The SUR of MA user was significantly decreased compared with healthy volunteers. The SUR of T3 is higher than T2, T2 is higher than T1 (all P≤0.05).
Conclusions These findings indicate that the striatal dopamine transporters densities of methamphetamine abusers decreased compared with healthy volunteers and the decreased SUR can be reversed in a short period of abstinence