Abstract
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Objectives The reductions of striatal DAT levels are inversely correlated with the severity of motor dysfunction in PD patients. However, there is no study about correlation between IPD and cognitive dysfunction. Thus we evaluated the differences of regional DAT density of brain between IPD without dementia and IPD with dementia using FP-CIT PET.
Methods FP-CIT PET study was conducted on seven patients with IPD without dementia, 17 patients with IPD with dementia and 18 healthy controls. Scans using FP-CIT PET were acquired on 1 hour and 3 hours after the FP-CIT injection.
Results Dopamine transporter density in both caudate nucleus and putamen, which were measured at 1 hour and 3 hours after FP-CIT injection, is no differences between patient with IPD without dementia and those with dementia, significantly. But DAT density of two groups with IPD demonstrated more decreased density than that of healthy controls group at putamen, especially, posterior putamen, significantly.
Conclusions These results suggested that reduction in DAT levels of striatum didn’t show healthy control groups but all patients with IPD. However, we cautiously insist that there is no relationship between DAT density and cognitive severity, because there are no significant differences between IPD with dementia and without dementia