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Research ArticleBrief Communications

Extravasation of a Therapeutic Dose of 131I-Metaiodobenzylguanidine: Prevention, Dosimetry, and Mitigation

Dacian V. Bonta, Raghuveer K. Halkar and Naomi Alazraki
Journal of Nuclear Medicine September 2011, 52 (9) 1418-1422; DOI: https://doi.org/10.2967/jnumed.110.083725
Dacian V. Bonta
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Raghuveer K. Halkar
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Naomi Alazraki
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  • FIGURE 1.
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    FIGURE 1.

    Patient forearm, on follow-up visit (about 7 wk after therapy), with radiation skin injury demonstrating moist desquamation.

  • FIGURE 2.
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    FIGURE 2.

    Posttherapy scan of abdomen, with arm at side, demonstrating persistent retention of radiotracer at site of extravasation (500 cps).

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    FIGURE 3.

    Putative distribution of radioactive source. Radioactive extravasate (Ο) mixed with dermis irradiates basal/germinative epidermal layer.

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    TABLE 1A

    Ratio of Photon Dose to β-Dose

    Collection thickness (cm)131I153Sm177Lu18F68Ga124I
    0.54.5%1.3%0.7%10.5%1.5%7.2%
    17.5%2.0%1.1%17.4%2.5%11.9%
    1.59.8%*2.6%1.5%22.9%*3.3%15.6%
    • * Results verified by Monte Carlo simulation.

    • For β− emitters, collections are assumed to have radius 1/μ, where μ is mass attenuation coefficient for dominant photon energy. For positron emitters, collections are assumed to have radius of 10 cm.

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Journal of Nuclear Medicine: 52 (9)
Journal of Nuclear Medicine
Vol. 52, Issue 9
September 1, 2011
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Extravasation of a Therapeutic Dose of 131I-Metaiodobenzylguanidine: Prevention, Dosimetry, and Mitigation
Dacian V. Bonta, Raghuveer K. Halkar, Naomi Alazraki
Journal of Nuclear Medicine Sep 2011, 52 (9) 1418-1422; DOI: 10.2967/jnumed.110.083725

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Extravasation of a Therapeutic Dose of 131I-Metaiodobenzylguanidine: Prevention, Dosimetry, and Mitigation
Dacian V. Bonta, Raghuveer K. Halkar, Naomi Alazraki
Journal of Nuclear Medicine Sep 2011, 52 (9) 1418-1422; DOI: 10.2967/jnumed.110.083725
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