Article Figures & Data
Figures
- FIGURE 1.
Mean time–activity curves (bars represent 1 SD) of 18F-LBT-999 corresponding to whole brain (A), regional uptake (B), specific binding (C), and ratio to cerebellum (D).
- FIGURE 2.
Representative mean image of 18F-LBT-999 from 9 to 240 min at level of striatum (A) and midbrain (B).
- FIGURE 3.
Representative high-performance liquid chromatogram (A) and mean plasma composition (bars represent 1 SD) after injection of 18F-LBT-999 (B).
- FIGURE 4.
Mean arterial blood and plasma parent radioactivity (% SUV) (bars represent 1 SD) after injection of 18F-LBT-999.
- FIGURE 5.
Comparison of fitting with 1-TCM or 2-TCM.
- FIGURE 6.
Relationship between distribution volume and duration of image analysis.
- FIGURE 7.
Uptake of 18F-LBT-999 (percentage injected dose) in different organs (A), reminder of body, spine, bone, and bladder (B).
Tables
VT VND Model Caudate Putamen Midbrain Thalamus Cerebellum 1-TCM 309.3 ± 80.2 352.5 ± 118.1 31.3 ± 12.5 10.1 ± 2.0 5.0 ± 1.3 2-TCM 508.8 ± 198.8 804.3 ± 726.1 38.2 ± 14.7 13.0 ± 1.4 8.3 ± 2.2 Logan 295.4 ± 63.8 333.3 ± 62.0 36.5 ± 12.3 14.0 ± 1.4 10.2 ± 1.7 χ2 1-TCM 1.4 ± 0.6 1.2 ± 0.3 6.8 ± 5.6 9.0 ± 1.4 12.4 ± 4.0 2-TCM 0.1 ± 0.0 0.1 ± 0.0 0.7 ± 0.4 1.1 ± 0.4 1.6 ± 1.0 Model selection criterion 1-TCM 3.7 ± 0.5 3.8 ± 0.3 2.1 ± 0.4 2.7 ± 0.2 3.0 ± 0.4 2-TCM 6.1 ± 0.2 6.4 ± 0.4 4.2 ± 0.6 4.8 ± 0.5 5.1 ± 0.7 BPF Model Caudate Putamen Midbrain Thalamus 1-TCM 915.6 ± 245.9 1,028.6 ± 274.3 78.8 ± 35.8 15.3 ± 4.5 2-TCM 1,484.5 ± 526.4 2,288.8 ± 1,914.9 89.0 ± 46.4 14.1 ± 7.6 Logan 852.2 ± 161.7 962.5 ± 112.1 78.6 ± 39.5 11.2 ± 6.4 - TABLE 3
BPND of 18F-LBT-999 Calculated Using 1-TCM, 2-TCM, and Logan GA and Estimated Using 4 Reference Tissue Models (FRTM, SRTM, Logan Ref, and MRTM2)
BPND Model Caudate Putamen Midbrain Thalamus 1-TCM 63.1 ± 18.7 75.2 ± 41.2 5.6 ± 2.9 1.1 ± 0.6 2-TCM 68.2 ± 42.7 120.2 ± 144.4 4.1 ± 2.8 0.7 ± 0.5 Logan 29.3 ± 10.8 32.9 ± 11.0 2.8 ± 1.6 0.4 ± 0.3 FRTM 19.4 ± 2.9 19.8 ± 1.9 3.2 ± 1.4 0.7 ± 0.3 SRTM 19.6 ± 3.1 19.8 ± 1.9 3.2 ± 1.4 0.7 ± 0.3 Logan Ref 18.1 ± 3.1 18.8 ± 2.4 3.1 ± 1.4 0.7 ± 0.3 MRTM2 18.1 ± 2.9 18.8 ± 2.3 3.2 ± 1.5 0.7 ± 0.3 Total dose (mGy/MBq) Mean total dose (mGy/MBq) Target organ Monkey 5 Monkey 6 Urinary bladder wall 0.088 0.144 0.116 Thyroid 0.088 0.078 0.083 Osteogenic cells 0.075 0.048 0.061 Upper large intestine wall 0.038 0.046 0.042 Small intestine 0.034 0.041 0.038 Kidneys 0.043 0.030 0.036 Brain 0.028 0.023 0.026 Red marrow 0.027 0.018 0.023 Lower large intestine wall 0.017 0.020 0.018 Heart wall 0.020 0.013 0.017 Uterus 0.012 0.015 0.014 Lungs 0.013 0.010 0.012 Gallbladder wall 0.011 0.011 0.011 Ovaries 0.010 0.012 0.011 Spleen 0.010 0.008 0.009 Liver 0.010 0.007 0.008 Total body 0.009 0.008 0.008 Adrenals 0.007 0.005 0.006 Pancreas 0.006 0.005 0.005 Muscle 0.005 0.005 0.005 Stomach wall 0.005 0.004 0.005 Testes 0.004 0.005 0.004 Thymus 0.004 0.003 0.003 Skin 0.003 0.003 0.003 Breasts 0.003 0.002 0.002 ED equivalent (mSv/MBq) 0.027 0.028 0.027 ED (mSv/MBq) 0.021 0.022 0.021
Supplemental Data
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