Abstract
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Objectives With a slip-ring rotational dual-head gamma camera, continuous SPECT data acquisition for dynamic drug challenge study became feasible. We designed a 5-sphere phantom and performed a continuous 2160-degree SPECT acquisition with arbitrary time-frame shifting reconstruction to simulated drug challenge study.
Methods Continuous six 360-degree SPECT acquisition (5 min/360degree, total 30 min) was performed by a slip-ring SPECT. At the first 12 min of the dynamic SPECT data acquisition, 1.42 MBq/ml concentration of Tc-99m pertechnetate water solution was infusion into a 5-sphere phantom by 15ml/min. Thereafter, non-radioactive water was infusion into the phantom in the following 18 min. The 5 spheres connected each other by a tube. Time activity curves were generated from each sphere.
Results From the 2160-degree SPECT acquisition experiment, time activity curves with 6, 11, and 22 time-point were generated from the original SPECT and arbitrary time-frame shifting reconstruction images. With additional arbitrary time-frame reconstruction, there were more observation points for the possible small changes of radioactivity in the phantom. The dynamic change of radioactivity in the different spheres of phantom can be better demonstrated with additional time-frame reconstruction.
Conclusions This experiment demonstrated the feasibility of continuous SPECT and arbitrary time-frame shifting reconstruction to obtain more observation time-point for better monitoring the change of radioactivity with time. This technique can be used in drug challenge study such as diuretic renal study and brain neuroreceptor occupancy study