Abstract
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Objectives We aimed to define the reproducibility and minimal detectable changes of key quantitative and visual motion and perfusion parameters which can be derived by automated software and expert visual observer from gated myocardial perfusion SPECT scans (MPS).
Methods Standard QGS/QPS algorithms have been applied to derive quantitative perfusion and motion parameters in 200 Tc-99m sestamibi stress/rest MPS scans, obtained in 100 consecutive patients who underwent 2 separate gated stress/rest scans on the same camera. Variables included stress, rest and ischemic total perfusion deficit (TPD) and ejection fraction. Visual perfusion/motion scores were derived by an expert using randomized scan order and normalized to % myocardium (% Myo).
Results results are shown in Table. Quantitative and visual parameters were highly reproducible with smaller minimal detectable changes (repeat coefficient) for rest quantitative measures as compared to visual measures (P < 0.0001). Minimal detectible changes for TPD were 3% for stress, 2% for rest and 3% for ischemic TPD. Visual scoring was more reproducible for thickening than for motion (P < 0.0001). Stress EF had lower minimal detectible change than Rest EF (P = 0.0048).
Conclusions This study demonstrates that standard perfusion and function parameters derived by expert visual or quantitative analysis are highly reproducible with some advantages of the quantitative approach.
Research Support This research was supported in part by grant R0HL089765-01 from the National Heart,Lung, and Blood Institute/National Institutes of Health (NHLBI/NIH)