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Meeting ReportNeurosciences: Neurology

[C-11]BF-227 PET imaging of amyloid deposition in AD, MCI, and normal subjects

Takashi Kato, Kengo Ito, Kentaro Hatano, Akinori Nakamura, Nobuyuki Okamura and Kazuhiko Yanai
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 426;
Takashi Kato
1National Center for Geriatrics and Gerontology, Dept of Brain Science and Molecular Imaging, Obu, Japan
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Kengo Ito
1National Center for Geriatrics and Gerontology, Dept of Brain Science and Molecular Imaging, Obu, Japan
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Kentaro Hatano
1National Center for Geriatrics and Gerontology, Dept of Brain Science and Molecular Imaging, Obu, Japan
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Akinori Nakamura
1National Center for Geriatrics and Gerontology, Dept of Brain Science and Molecular Imaging, Obu, Japan
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Nobuyuki Okamura
2Tohoku University, Dept of Pharmacology, Sendai, Japan
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Kazuhiko Yanai
2Tohoku University, Dept of Pharmacology, Sendai, Japan
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Abstract

426

Objectives [C-11] BF-227 (2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)- 6-(2-[fluoro]ethoxy) benzoxazole) is a PET probe for detection of dense amyloid deposits, which has been developed in Tohoku University. The purpose of this study was to evaluate BF-227 binding in normal subjects, patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI).

Methods The subjects were seven patients with AD (mean age 73+/-11 years old), eight patients with MCI (age 69+/-10 y.o.), and 15 healthy normal volunteers (NCn15, age 68+/-4 y.o.). They underwent Brain [C-11]BF-227 PET, 3D-MR imaging, and neuropsychological tests. BF-227 dynamic PET was performed for 60 min after the injection of 370-740 MBq [C-11] BF-227. Spatially normalized SUVR images were calculated from static 20-40 min images using the reference values in the cerebellar region of interest (ROI). Fifteen normal subjects were divided into 11 subjects with low SUVR (NCn11, age 69+/-5 y.o.) and four subjects with high SUVR by leave-one-out cross-validation. Statistical comparisons and correlation analyses were performed on voxel-by-voxel (SPM) and ROI basis.

Results AD showed higher accumulation of BF-227 in the parieto-temporal, medial frontal, precuneus, and posterior cingulate areas than NCn11 (p<0.05, ext>200). MCI showed intermediate binding between AD and NCn11 in voxel-based and ROI analyses. The SUVR ROI value was inversely correlated with MMSE (p<0.05) and WMS-R logical memory II (p<0.05).

Conclusions The results suggest that BF-227 binding corresponds to pathological and symptomatic progression from normal to AD.

  • © 2009 by Society of Nuclear Medicine
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Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
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[C-11]BF-227 PET imaging of amyloid deposition in AD, MCI, and normal subjects
Takashi Kato, Kengo Ito, Kentaro Hatano, Akinori Nakamura, Nobuyuki Okamura, Kazuhiko Yanai
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 426;

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[C-11]BF-227 PET imaging of amyloid deposition in AD, MCI, and normal subjects
Takashi Kato, Kengo Ito, Kentaro Hatano, Akinori Nakamura, Nobuyuki Okamura, Kazuhiko Yanai
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 426;
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