Abstract
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Objectives It is reported that FDG PET show diagnostic performance comparable to MR in detecting liver metastasis(LM) from colorectal cancer. However, not only studies including large number of patients, also with superparamagnetic iron oxide (SPIO) and gadolinium(Gd)-enhanced MR are limited. The aim of this study is to compare PET/CT and SPIO and/or Gd-enhanced MR for detection of LM.
Methods Among 182 patients, total 140 patients (M:F=93:47, age=60±11, staging: 102, recurrence: 38) were included in this study who underwent MR (SPIO;24, Gd;40, SPIO and Gd;76) and PET within one month between March, 2002 and august, 2008. 403 liver lesions from 140 patients were evaluated. PET and MR results were compared with pathologic reports and follow-up imaging.
Results Of the 403 lesions, 322 lesions (79.9%) were diagnosed as LMs, while remaining 81 (20.1%) as benign. On per-patient bases, the sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV) of PET/CT were 96.5%, 81.5%, 94.8% and 88%, compared to 96.5%, 81.5%, 96.5%, and 81.5% for MR. On per-lesion bases, the sensitivity, specificity, PPV, and NPV of PET/CT were 77.6%, 74.1%, 91.6% and 46.2%, compared to 86.0%, 40.7%, 85.0%, and 42.9% for MR. Additionally, on per-segment base analysis PET/CT showed 63.7%, 54.5%, 77.7%, 37.7% and MR showed 75.2%, 37.7%, 74.4%, 38.7%.
Conclusions FDG PET/CT showed same sensitivity and specificity with SPIO and/or Gd MR on per-patient bases. On per-lesion and per-segment bases, FDG PET/CT showed higher sensitivity but lower specificity than SPIO and/or Gd MR.
- © 2009 by Society of Nuclear Medicine