Abstract
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Objectives To evaluate pronostic value of pretherapeutic PETand pelvic MRI in cervical cancer.
Methods 53 patients underwent FDG and MRI prior to initiation of cervical cancer treatment were retrospectively evaluated. Visual analysis of PET was performed with special care given to uterine cervix, pelvic and para-aortic nodes. MRI evaluated pelvic nodes, volume and spreading of the tumour. Predictive values for recurrence or death after one year were calculated. Mann-Whitney univariate analysis and Cox multivariate analysis were performed.
Results Using univariate analysis, predictive factors for recurrence were PET pelvic (p=0,005), PET para-aortic (p=0,0002) node involvement, and pelvic node involvement on MRI (p=0,002).Multivariate analysis revealed that the only predictive factor for recurrence was a PET pelvic node involvement (OR=14 , p=0,0004). Factors predicting overall survival were pelvic (p=0,005) and para-aortic (p=0,0002) node involvement on PET/CT.
Conclusions PET pelvic lymph node involvement is an independant prognostic factor for recurrence and death in the year following diagnosis and treatment of cervical cancer. Although MRI is needed for pretherapeutic staging, it did not provide any additional prognostic information.
- © 2009 by Society of Nuclear Medicine