Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Follow JNM on Twitter
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Subscribe to our RSS feeds
Meeting ReportOncology - Basic: Basic Science

PET (18F-FDG) and SPECT (99mTc-1) agents in preclinical models of melanoma metastasis in mice

Naengnoi Limpa-Amara, Robert Zimmerman, Alun Jones and Ashfaq Mahmood
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1603;
Naengnoi Limpa-Amara
1Department of Radiology, Harvard Medical School, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert Zimmerman
1Department of Radiology, Harvard Medical School, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alun Jones
1Department of Radiology, Harvard Medical School, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ashfaq Mahmood
1Department of Radiology, Harvard Medical School, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

1603

Objectives The imaging of melanoma with [18F]-FDG and [99mTcOAADT]-(CH2)2-N(Et)2 (99mTc-1) was studied using both a subcutaneous tumor model and a B16/F10 metastasis model where small melanoma lesions occur in mouse lungs.

Results [18F]-FDG displayed subcutaneous tumor uptake of 4.92±0.24, 6.28±0.96 and 3.98±0.73 %ID/g at 1, 3, and 6 h, respectively, while 99mTc-1 displayed a significant and comparable tumor uptake of 7.6±1.3, 6.6±2.16 and 4.72±1.9 %ID/g.In the metastasis model, [18F]-FDG displayed tumor-lung uptake of 2.03±0.58, 3.67±0.69, 2.09±0.2, and 1.78±0.5 %ID/g at 0.5, 1, 2, and 3 h respectively, compared to normal lung uptake of 1.67±0.1, 2.56±0.4, 2.12±0.3 and 2.1±0.26 %ID/g. 99mTc-1 displayed a significant tumor uptake in the melanotic lesions with the tumor uptake of 10.35±1.6 and 3.82±0.9 %ID/g at 2 and 3 h p.i, respectively, compared to 2.13±0.20 and 0.85±0.26 %ID/g observed in the normal lung. Exvivo radiophosphor imaging of the excised tumor-lungs also confirmed the uptake differences between [18F]-FDG and the 99mTc-1 complex. Distinct visualization of the small tumor lesions within the mouse lungs was also achievable with 99mTc-1 by µSPECT imaging.

Conclusions In both murine melanoma models [18F]-FDG displayed a significant washout from the melanoma tumors over time, presumably due to the phosphatase activity in these tumors. The lack of [18F]-FDG accumulation observed in the small metastatic lesions in the lungs may also be due to a higher blood-flow-dependent washout. 99mTc-1, however, displayed high and specific uptake in melanotic melanomas in both tumor models.

  • © 2009 by Society of Nuclear Medicine
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
PET (18F-FDG) and SPECT (99mTc-1) agents in preclinical models of melanoma metastasis in mice
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
PET (18F-FDG) and SPECT (99mTc-1) agents in preclinical models of melanoma metastasis in mice
Naengnoi Limpa-Amara, Robert Zimmerman, Alun Jones, Ashfaq Mahmood
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1603;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
PET (18F-FDG) and SPECT (99mTc-1) agents in preclinical models of melanoma metastasis in mice
Naengnoi Limpa-Amara, Robert Zimmerman, Alun Jones, Ashfaq Mahmood
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1603;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Oncology - Basic: Basic Science

  • The ratio of maximum percent tumor accumulations of pretargeting agent and radiolabeled effector does not change with tumor size
  • Monitoring therapy effects of adoptive T-cell transfer in a murine model of gastric carcinoma with F18-FDG-PET
  • Overexpression of peptide receptors as target for PET or SPECT radiopharmaceuticals: A tissue microarray (TMA) study
Show more Oncology - Basic: Basic Science

Basic Science Posters

  • Evaluation of 18F-clofarabine as a PET probe of deoxycytidine kinase in mouse and rat models of glioblastoma
  • Imaging of lipid synthesis in hepatocellular carcinoma correlated with metabolism study in vivo
  • Physiochemical characterization and radiolabeling of tamoxifen-cyclodextrin complex for breast cancer therapy
Show more Basic Science Posters

Similar Articles

SNMMI

© 2023 Journal of Nuclear Medicine

Powered by HighWire