Abstract
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Objectives The objective of the study was to assess the performance of the LMC versus 2D echocardiography in the estimation of the LVEF in comparison to QGS, ECTb, and LVGTF methods.
Methods Thirty-eight patients were retrospectively collected for the study (27 males). All patients underwent myocardial perfusion gated SPECT and 2D echo within less than two weeks. EF estimated by the four methods and echo were recorded and statistically analyzed.
Results The mean EF by echo was significantly higher than QGS and LMC (p<0.0001 and p=0.003 respectively) whereas it was significantly lower than ECTb and LVGTF methods (p=0.02 and p= 0.001 respectively). QGS, ECTb, and LMC correlated well in the measurements of the EF with echo (r=0.844, 0.825, and 0.700), however, a lower correlation was found between LVGTF and echo (r=0.595). The variation of these differences as indicated by SD revealed an agreement limits of (-7.6,16.1) and (10.5,-15.7) for QGS and ECTb respectively while it was (-11.6,19.6) and (-27.9,15.7) for LMC and LVGTF respectively.
Conclusions All methods showed a significant correlation with echo in the calculation of the EF. However, the strength of correlation varied among methods. LMC method showed close results to that obtained by QGS and ECTb with similar variability as demonstrated by agreement analysis. The study has investigated the utility of using LMC method in clinical practice, however, it will be more applicable when it becomes an independent and extensively validated with other accurate techniques.
- © 2009 by Society of Nuclear Medicine