Abstract
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Objectives Fast dynamic SPECT measurements of arterial input functions (AIF) could permit kinetic model-based quantitation of cardiac MBF, despite known projection inconsistencies in measurement. We present preliminary dynamic SPECT AIF patient data. We validate our measurement with comparisons to phantom database time activity curves (TACs) and integrals.
Methods SPECT/CT patient data were acquired (Philips Precedence) during a 2-min 7-mCi 99mTc-tetrofosmin infusion. The cameras (2 heads, 90o) made eight 180o rotations, (54 sec and 36 angles each, 3 sec/angle). TACs were calculated from regions within the left atrium (LA), myocardium (MY) and liver, derived from the CT.Patient data were compared with an anthropomorphic phantom projection database (Sitek et al, JNM 47, 1187-1192, 2007) using input TACs of left ventricular (LV), MY and liver activity modeled from 2-min 94mTc-MIBI infusion human PET data.
Results Qualitative assessments of LA, MY and liver TACs were made from the patient data. LV TACs and integrals were assessed from the database-generated images. The integrals from the database TACs and from the patient TACs were highly correlated (r=0.99, p<0.001).
Conclusions The LA TACs from SPECT patient studies agreed well with the phantom database measurements. The high correlation of the integrals indicates that measurement of AIF with dynamic SPECT may be possible.
Research Support California Discovery Grant, Philips Healthcare
- © 2009 by Society of Nuclear Medicine