Abstract
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Objectives Aim of the work was to compare three methods to calculate SBR and APC to find wich of them is more suitable to determine the APC. The methods compared were: the 3D BasalGangliaMatchingTools (BGMT) method the semiautomated QuantiSpect (QS) and a method based on manually drawn regions of interest (MR)
Methods After injection of FPCIT 13 PD patients were scanned at baseline and follow-up by a Prism3000 with LEUHRFAN collimators. Quantification of SBR was assessed by all three methods and used to determine APC values. For 3 patients data processing was repeated twice with each methods to evaluate intra-operator variability of SBR as Coefficient of Variance (CV). The methods were compared by means of the average of APC values (AvgAPC) calculated for each patient and the maximum of CVvalues(MaxCV)
Results The AvgAPC values were 12.4±13 for BGMT, 11.7±9 for MR and 15.9±14 for QS. The MaxCV values were 5% for BGMT, 12% for MR and 22% for QS.
Conclusions These results show that APC values for QS (15.9) are higher than BGMT (12.4) and MR (11.7) methods however the variability expressed as MaxCVfor BGMT (5) method is markedly lower than MR (12) and QS (22) methods. The BGMT method offer the best compromise between high APC values and low intra-operator variability and seems more indicated than QS and MR to calculate APC.
- © 2009 by Society of Nuclear Medicine