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Baseline volume-rendered ¹⁸F-FDG PET/CT demonstrates high metabolic activity in primary tumor in right upper lobe (cross-hairs) and additional metabolically active foci corresponding to hilar and mediastinal lymph nodes, extending to thoracic inlet superiorly. After treatment, metabolic abnormality at all previous sites of disease had decreased significantly, suggesting favorable metabolic response. PET/CT allows evaluation of both morphologic and metabolic response and comparison of these parameters on lesion-by-lesion basis. Volumetric display, such as in these representations, can help clinicians to understand distribution of disease and to plan treatment.