I. Zolle, ed.
New York, NY: Springer, 2007, 345 pages, $169
Written by a panel of 21 experts in the field and edited by Ilse Zolle, this hardbound volume is the current authoritative desk reference for those working with 99mTc-labeled radiopharmaceuticals. The 11 chapters of part 1 provide concise, but comprehensive and well-referenced, accounts of the chemistry of technetium and its ligands, the design of biologically active 99mTc-labeled conjugates, the preparation and quality control of 99mTc-labeled radiopharmaceuticals, the particulars of generators and sterile kit formulations, and the regulatory aspects of radiopharmaceutical manufacture from the European viewpoint. Part 2 comprises 11 main monographs that cover the 99mTc-labeled radiopharmaceuticals that are widely used in nuclear medicine. Pertechnetate; colloids; brain and heart perfusion agents; bone, renal, and hepatobiliary agents; and labeled peptides, proteins, antibodies, and cells are covered in depth. The monographs include details on chemistry, trade names, kit components, preparation, formulation, storage, stability, and quality control. Each monograph also includes sections on clinical pharmacokinetics, radiation dosimetry, and the most common clinical applications. These monographs are organized for ready retrieval of information and include pertinent primary references. Case studies and clinical nuance are beyond the scope of this work, which is an outgrowth of the European Working Group on the Quality Control of 99mTc-Radiopharmaceuticals. Forewords by Drs. Henry Wagner and Christoph Reiners provide perspective, and appendices on pediatric radiopharmacy round out the text.
This nicely organized and clearly illustrated book provides an up-to-date resource for radiopharmacists and nuclear medicine physicians who compound and prescribe 99mTc-labeled radiopharmaceuticals. Radiochemists and those concerned with regulatory affairs also will be interested, and the book could be used as a primary text in nuclear medicine training programs. This outstanding book fills a void and is the first compilation of its kind in many years. We recommend it with the highest enthusiasm.
Footnotes
-
COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.