This Month in JNM
=================


**Small-animal cardiovascular imaging:** Tsui and Kraitchman review recent technologies, new applications, and promising translational aspects of experimental cardiovascular molecular investigations with MR, optical, CT, and radionuclide-based imaging.  
</br> ***[Page 667](http://jnm.snmjournals.org/lookup/volpage/50/667?iss=5)*** 

![Figure1](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F1.medium.gif)

[Figure1](http://jnm.snmjournals.org/content/50/5/11A/F1)

**Quest for infection imaging:** Palestro provides an overview of current studies and challenges in radionuclide labeling of leukocytes and previews 2 articles in this issue of *JNM* with innovative approaches to sensitive and specific in vivo detection of infection.  
</br> ***[Page 671](http://jnm.snmjournals.org/lookup/volpage/50/671?iss=5)***

**List mode–driven gating in PET:** Büther and colleagues evaluate several cardiac and respiratory gating methods designed to reduce motion effects in PET and describe a simple and easily implemented solution.  
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![Figure2](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F2.medium.gif)

[Figure2](http://jnm.snmjournals.org/content/50/5/11A/F2)

**PET in liver transplantation:** Lee and colleagues investigate the ability of 18F-FDG PET to identify appropriate candidates for liver transplantation for hepatocellular carcinoma and to predict tumor recurrence after surgery.  
</br> ***[Page 682](http://jnm.snmjournals.org/lookup/volpage/50/682?iss=5)*** 

![Figure3](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F3.medium.gif)

[Figure3](http://jnm.snmjournals.org/content/50/5/11A/F3)

**Imaging before microsphere embolization:** Hamami and colleagues describe the use of 99mTc-macroaggregated albumin SPECT/CT for detection of gastrointestinal shunting before radioembolization with 90Y microspheres in patients with hepatocellular carcinoma.  
</br> ***[Page 688](http://jnm.snmjournals.org/lookup/volpage/50/688?iss=5)*** 

![Figure4](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F4.medium.gif)

[Figure4](http://jnm.snmjournals.org/content/50/5/11A/F4)

**HRRT spatial resolution and accuracy:** van Velden and colleagues compare the quantitative accuracy and spatial resolution of high-resolution research tomography with that of a clinical HR+ PET scanner in brain imaging of healthy volunteers.  
</br> ***[Page 693](http://jnm.snmjournals.org/lookup/volpage/50/693?iss=5)***

**Novel D2 receptor radioligand:** Otsuka and colleagues report on the kinetics and quantification of 11C-MNPA, a new agonist radioligand for PET imaging of the high-affinity state of dopamine D2 receptors in the human brain.  
</br> ***[Page 703](http://jnm.snmjournals.org/lookup/volpage/50/703?iss=5)*** 

![Figure5](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F5.medium.gif)

[Figure5](http://jnm.snmjournals.org/content/50/5/11A/F5)

**PET in chromaffin-derived tumors:** Taïeb and colleagues evaluate tracer uptake in patients with chromaffin-derived tumors, with results that suggest that 18F-FDG avidity in pheochromocytomas and paragangliomas can be considered a new “molecular imaging signature” of disease.  
</br> ***[Page 711](http://jnm.snmjournals.org/lookup/volpage/50/711?iss=5)*** 

![Figure6](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F6.medium.gif)

[Figure6](http://jnm.snmjournals.org/content/50/5/11A/F6)

**Phase analysis for LV dyssynchrony:** Boogers and colleagues validate a quantitative gated SPECT algorithm for phase analysis in myocardial perfusion detection of left ventricular dyssynchrony and compare the results with those from echocardiography using tissue Doppler imaging.  
</br> ***[Page 718](http://jnm.snmjournals.org/lookup/volpage/50/718?iss=5)*** 

![Figure7](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F7.medium.gif)

[Figure7](http://jnm.snmjournals.org/content/50/5/11A/F7)

**Liquid gastric emptying:** Ziessman and colleagues assess whether a 30-min study of clear liquid gastric emptying can add diagnostic value to a study of solid emptying alone in the detection of gastroparesis.  
</br> ***[Page 726](http://jnm.snmjournals.org/lookup/volpage/50/726?iss=5)***

**131I and rhTSH in nontoxic goiter:** Fast and colleagues explore optimal time intervals between recombinant human thyroid-stimulating hormone and radioiodine administration to enhance thyroid uptake in patients with symptomatic nontoxic goiter.  
</br> ***[Page 732](http://jnm.snmjournals.org/lookup/volpage/50/732?iss=5)***

**Radiotracer imaging in breast cancer:** Lee and colleagues provide the second in a series of educational overviews of the current role of radiotracer imaging in breast cancer, focusing on management strategies, newer nonnuclear techniques, and future directions.  
</br> ***[Page 738](http://jnm.snmjournals.org/lookup/volpage/50/738?iss=5)***

**11C-Rolipram binding in conscious rats:** Itoh and colleagues measure the binding site density and radioligand affinity of this selective inhibitor of a key intracellular messenger in the rat brain and evaluate the effects of anesthesia in small-animal PET.  
</br> ***[Page 749](http://jnm.snmjournals.org/lookup/volpage/50/749?iss=5)*** 

![Figure8](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F8.medium.gif)

[Figure8](http://jnm.snmjournals.org/content/50/5/11A/F8)

**sr39tk PET imaging:** Johnson and colleagues determine the minimum number of human simplex virus type-1 thymidine kinase sr39tk–expressing tumor cells needed for 18F-FBHG PET detection and describe the potential for monitoring therapeutic gene expression in metastatic disease.  
</br> ***[Page 757](http://jnm.snmjournals.org/lookup/volpage/50/757?iss=5)*** 

![Figure9](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F9.medium.gif)

[Figure9](http://jnm.snmjournals.org/content/50/5/11A/F9)

**Cell-based therapy for osteoporosis:** Lo and colleagues report on the use of fibroblasts in combination with platelet-rich plasma to achieve cell-based bone regeneration in osteoporotic mice and on monitoring regeneration with fluorescence imaging.  
</br> ***[Page 765](http://jnm.snmjournals.org/lookup/volpage/50/765?iss=5)*** 

![Figure10](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F10.medium.gif)

[Figure10](http://jnm.snmjournals.org/content/50/5/11A/F10)

**18F-FBnTP apoptosis detection:** Madar and colleagues characterize the ability of the novel PET voltage sensor 18F-FBnTP to quantify the time-dependent apoptotic action of the taxanes paclitaxel and docetaxel in vitro and in vivo.  
</br> ***[Page 774](http://jnm.snmjournals.org/lookup/volpage/50/774?iss=5)***

**99mTc-labeled recombinant Affibody:** Ahlgren and colleagues describe the characteristics and potential advantages of the Affibody molecule 99mTc-ZHER2:2395-Cys as a promising tracer for SPECT visualization of human epidermal growth factor receptor type-2 expression in malignant tumors.  
</br> ***[Page 781](http://jnm.snmjournals.org/lookup/volpage/50/781?iss=5)***

**Peptide-based imaging of inflammation:** Locke and colleagues detail the synthesis and validation of a new, highly potent 64Cu-labeled peptide, cFLFLF-PEG-64Cu, that targets the formyl peptide receptor on leukocytes.  
</br> ***[Page 790](http://jnm.snmjournals.org/lookup/volpage/50/790?iss=5)*** 

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[Figure11](http://jnm.snmjournals.org/content/50/5/11A/F11)

**Imaging P-gp inhibition in pregnancy:** Eyal and colleagues test in primates the feasibility of whole-body PET for simultaneous, serial, noninvasive imaging of P-glycoprotein activity and inhibition in multiple maternal organs and the placenta.  
</br> ***[Page 798](http://jnm.snmjournals.org/lookup/volpage/50/798?iss=5)***

**Brain imaging with 11C-dLop:** Seneca and colleagues investigate whether this radiolabeled metabolite of loperamide is a promising PET tracer to study the function of P-glycoprotein at the blood–brain barrier in humans.  
</br> ***[Page 807](http://jnm.snmjournals.org/lookup/volpage/50/807?iss=5)*** 

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[Figure12](http://jnm.snmjournals.org/content/50/5/11A/F12)

**11C-NPA biodistribution and dosimetry:** Laymon and colleagues report on the whole-body distribution of this dopamine agonist PET tracer and resulting absorbed radiation doses in human subjects.  
</br> ***[Page 814](http://jnm.snmjournals.org/lookup/volpage/50/814?iss=5)***

**Dosimetry of 18F-GE067:** Koole and colleagues characterize the biodistribution and dosimetry of 18F-GE067, a newly developed radioligand for PET visualization and quantification of amyloid burden, in healthy elderly men and women.  
</br> ***[Page 818](http://jnm.snmjournals.org/lookup/volpage/50/818?iss=5)***

**Distinguishing infection from inflammation:** Liberatore and colleagues describe methods for 99mTc labeling of human β-defensin-3, an antimicrobial peptide with bactericidal effects, for evaluation of infection in experimental studies.  
</br> ***[Page 823](http://jnm.snmjournals.org/lookup/volpage/50/823?iss=5)*** 

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[Figure13](http://jnm.snmjournals.org/content/50/5/11A/F13)

**PET after liver transplantation:** Tsuji and colleagues explore the efficacy of a method for semiquantitative 18F-FDG PET detection of acute allograft rejection in a rodent model.  
</br> ***[Page 827](http://jnm.snmjournals.org/lookup/volpage/50/827?iss=5)***

## ON THE COVER

The biodistribution and dosimetry of 18F-flutemetamol, a newly developed radioligand to visualize and quantify amyloid burden, have been characterized. Here, PET slices through the brain of a healthy subject (top) and a patient with Alzheimer disease (bottom) show the distribution of uptake. Specific uptake is present in gray matter in patients, and aspecific uptake is seen in white matter, pons, and thalamus. Variability in dosimetry between subjects was relatively low.

See page [821](http://jnm.snmjournals.org/lookup/volpage/50/818?iss=5). 

![Figure14](http://jnm.snmjournals.org/https://jnm.snmjournals.org/content/jnumed/50/5/11A/F14.medium.gif)

[Figure14](http://jnm.snmjournals.org/content/50/5/11A/F14)