Administered Radiopharmaceutical Doses in Children: A Survey of 13 Pediatric Hospitals in North America | Journal of Nuclear Medicine

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TABLE 1

Study Data

Radiopharmaceutical	Parameter	Number of respondents	Minimum	Maximum	Median	Mean
^99mTc-dimercaptosuccinic acid (DMSA)	Activity/mass, MBq/kg (mCi/kg)	8	1.11 (0.030)	3.70 (0.100)	2.22 (0.060)	2.35 (0.064)
	Minimum activity, MBq (mCi)	11	5.55 (0.150)	74.00 (2.000)	18.50 (0.500)	26.40 (0.714)
	Maximum activity, MBq (mCi)	11	74.00 (2.00)	222.00 (6.000)	185.00 (5.000)	151.36 (4.091)
^99mTc-mercaptoacetyltriglycine (MAG3)	Activity/mass, MBq/kg (mCi/kg)	8	1.85 (0.050)	10.36 (0.280)	5.55 (0.150)	5.69 (0.154)
	Minimum activity, MBq (mCi)	12	18.50 (0.500)	148.00 (4.000)	37.00 (1.000)	53.96 (1.458)
	Maximum activity, MBq (mCi)	13	111.00 (3.000)	370.00 (10.000)	370.00 (10.000)	278.92 (7.538)
^99mTc-methylene diphosphate (MDP)	Activity/mass, MBq/kg (mCi/kg)	8	7.40 (0.200)	13.32 (0.360)	11.10 (0.300)	10.87 (0.294)
	Minimum activity, MBq (mCi)	13	22.20 (0.600)	185.00 (5.000)	92.50 (2.500)	99.90 (2.700)
	Maximum activity, MBq (mCi)	13	666.00 (18.000)	925.00 (25.000)	740.00 (20.000)	819.69 (22.154)
^99mTc-diisopropyl iminodiacetic acid (DISIDA)	Activity/mass, MBq/kg (mCi/kg)	7	1.85 (0.050)	3.70 (0.100)	2.78 (0.075)	2.97 (0.080)
	Minimum activity, MBq (mCi)	13	14.80 (0.400)	74.00 (2.000)	37.00 (1.000)	36.17 (0.978)
	Maximum activity, MBq (mCi)	13	92.50 (2.500)	370.00 (10.000)	185.00 (5.000)	200.65 (5.423)
¹²³I-metaiodobenzylguanidine (MIBG)	Activity/mass, MBq/kg (mCi/kg)	7	5.18 (0.140)	7.40 (0.200)	5.55 (0.150)	5.45 (0.147)
	Minimum activity, MBq (mCi)	11	37.00 (1.000)	185.00 (5.000)	37.00 (1.000)	75.68 (2.045)
	Maximum activity, MBq (mCi)	13	296.00 (8.000)	370.00 (10.000)	370.00 (10.000)	360.04 (9.731)
^99mTc-NaTcO₄ (for Meckel's diverticulum)	Activity/mass, MBq/kg (mCi/kg)	7	1.63 (0.044)	5.92 (0.160)	5.18 (0.140)	4.46 (0.121)
	Minimum activity, MBq (mCi)	12	7.40 (0.200)	148.00 (4.000)	37.00 (1.000)	49.27 (1.332)
	Maximum activity, MBq (mCi)	12	111.00 (3.000)	555.00 (15.000)	370.00 (10.000)	348.42 (9.417)
¹²³I (NaI) (for the thyroid)	Activity/mass, MBq/kg (mCi/kg)	4	0.06 (0.0015)	0.22 (0.0060)	0.10 (0.0028)	0.12 (0.0033)
	Minimum activity, MBq (mCi)	10	0.56 (0.0150)	11.10 (0.3000)	3.70 (0.1000)	3.76 (0.1015)
	Maximum activity, MBq (mCi)	11	3.70 (0.1000)	19.98 (0.5400)	8.14 (0.2200)	9.45 (0.2555)
^99mTc-ethylcysteinate dimer (ECD) or ^99mTc-exametazime (HMPAO)	Activity/mass, MBq/kg (mCi/kg)	7	1.85 (0.050)	15.73 (0.425)	10.55 (0.285)	10.81 (0.292)
	Minimum activity, MBq (mCi)	11	18.50 (0.500)	370.00 (10.000)	185.00 (5.000)	174.91 (4.727)
	Maximum activity, MBq (mCi)	12	370.00 (10.000)	1110.00 (30.000)	740.00 (20.000)	810.92 (21.917)
^99mTc-sestamibi (MIBI)	Activity/mass, MBq/kg (mCi/kg)	7	5.70 (0.154)	18.50 (0.500)	12.95 (0.350)	11.97 (0.323)
	Minimum activity, MBq (mCi)	10	37.00 (1.000)	518.00 (14.000)	148.00 (4.000)	210.90 (5.700)
	Maximum activity, MBq (mCi)	12	370.00 (10.000)	1110.00 (30.000)	777.00 (21.000)	792.42 (21.417)
^99mTc-macroaggregated albumin (MAA)	Activity/mass, MBq/kg (mCi/kg)	7	1.11 (0.030)	4.88 (0.132)	1.85 (0.050)	2.31 (0.062)
	Minimum activity, MBq (mCi)	12	7.40 (0.200)	37.00 (1.000)	18.50 (0.500)	21.40 (0.578)
	Maximum activity, MBq (mCi)	12	111.00 (3.000)	222.00 (6.000)	138.75 (3.750)	143.99 (3.892)
^99mTc-Ultratag (Mallinckrodt) (for gastrointestinal bleeding)	Activity/mass, MBq/kg (mCi/kg)	6	3.70 (0.100)	11.10 (0.300)	8.33 (0.225)	7.92 (0.214)
	Minimum activity, MBq (mCi)	9	37.00 (1.000)	148.00 (4.000)	74.00 (2.000)	78.11 (2.111)
	Maximum activity, MBq (mCi)	11	185.00 (5.000)	740.00 (20.000)	740.00 (20.000)	615.55 (16.636)
^99mTc-denatured RBCs (for the spleen)	Activity/mass, MBq/kg (mCi/kg)	2	1.85 (0.050)	2.59 (0.070)	2.22 (0.060)	2.22 (0.060)
	Minimum Activity MBq (mCi)	6	18.50 (0.500)	92.50 (2.500)	37.00 (1.000)	40.08 (1.083)
	Maximum Activity MBq (mCi)	6	74.00 (2.000)	740.00 (20.000)	111.00 (3.000)	215.83 (5.833)
^99mTc-Ultratag (Mallinckrodt) (for multiple gated acquisitions)	Activity/Mass MBq/kg (mCi/kg)	5	7.40 (0.200)	14.80 (0.400)	8.14 (0.220)	9.69 (0.262)
	Minimum Activity MBq (mCi)	10	44.40 (1.200)	370.00 (10.000)	101.75 (2.750)	132.09 (3.570)
	Maximum Activity MBq (mCi)	11	555.00 (15.000)	925.00 (25.000)	740.00 (20.000)	733.27 (19.818)
⁶⁷Ga (for inflammatory disease)	Activity/Mass MBq/kg (mCi/kg)	5	1.48 (0.040)	2.59 (0.070)	1.85 (0.050)	1.90 (0.051)
	Minimum Activity MBq (mCi)	4	9.25 (0.250)	74.00 (2.000)	27.75 (0.750)	34.69 (0.938)
	Maximum Activity MBq (mCi)	6	111.00 (3.000)	185.00 (5.000)	166.50 (4.500)	154.17 (4.167)
⁶⁷Ga (for tumor imaging)	Activity/Mass MBq/kg (mCi/kg)	5	2.96 (0.080)	5.25 (0.142)	4.07 (0.110)	3.90 (0.105)
	Minimum Activity MBq (mCi)	10	9.25 (0.250)	111.00 (3.000)	37.00 (1.000)	41.07 (1.110)
	Maximum Activity MBq (mCi)	12	222.00 (6.000)	370.00 (10.000)	333.00 (9.000)	312.96 (8.458)
¹⁸F-fluorodeoxyglucose (FDG)	Activity/Mass MBq/kg (mCi/kg)	6	5.18 (0.140)	7.40 (0.200)	5.37 (0.145)	5.67 (0.153)
	Minimum Activity MBq (mCi)	6	18.50 (0.500)	74.00 (2.000)	37.00 (1.000)	46.25 (1.250)
	Maximum Activity MBq (mCi)	8	370.00 (10.000)	555.00 (15.000)	407.00 (11.000)	430.13 (11.625)