Reducing the Incidence of 131I-Induced Sialadenitis: The Role of Pilocarpine

Edward B. Silberstein

doi:10.2967/jnumed.107.049411

Research ArticleCLINICAL INVESTIGATIONS

Reducing the Incidence of ¹³¹I-Induced Sialadenitis: The Role of Pilocarpine

Edward B. Silberstein

Journal of Nuclear Medicine April 2008, 49 (4) 546-549; DOI: https://doi.org/10.2967/jnumed.107.049411

Edward B. Silberstein

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TABLE 1

Patient Demographics

Parameter	Pilocarpine	No pilocarpine
Number of patients
Women	25	23
Men	7	5
Age (y)
Mean	47.3	46.6
SD	17.0	16.5
Cases of thyroid carcinoma
Papillary	28	25
Follicular	4	3
¹³¹I activity (GBq)
Mean	4.40	4.92
SD	1.42	1.92

For all comparisons, P > 0.05.

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TABLE 2
Symptoms After ¹³¹I Therapy
Symptom Pilocarpine (n = 32) No pilocarpine (n = 28)
Sialadenitis
Acute 1 (3%) 2 (7%)
Chronic 1 (3%) 0
Stomatitis or glossitis 5 (16%) 6 (21%)
Subjective xerostomia 0 0
Dysgeusia 2 (6%) 1 (4%)
For all comparisons, P > 0.05.

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Journal of Nuclear Medicine

Vol. 49, Issue 4

April 2008

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Reducing the Incidence of ¹³¹I-Induced Sialadenitis: The Role of Pilocarpine

Edward B. Silberstein

Journal of Nuclear Medicine Apr 2008, 49 (4) 546-549; DOI: 10.2967/jnumed.107.049411

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Reducing the Incidence of ¹³¹I-Induced Sialadenitis: The Role of Pilocarpine

Edward B. Silberstein

Journal of Nuclear Medicine Apr 2008, 49 (4) 546-549; DOI: 10.2967/jnumed.107.049411

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Symptom	Pilocarpine (n = 32)	No pilocarpine (n = 28)
Sialadenitis
Acute	1 (3%)	2 (7%)
Chronic	1 (3%)	0
Stomatitis or glossitis	5 (16%)	6 (21%)
Subjective xerostomia	0	0
Dysgeusia	2 (6%)	1 (4%)