Abstract
1060
Objectives: A novel solid-state gamma camera (SSGC) was recently developed. The SSGC has high spatial resolution and high energy resolution compared to a conventional scintillation gamma camera (CSGC). We evaluated 99mTc-sestamibi first-pass imaging and ECG-gated myocardial imaging employing a dog model. The SSGC data were compared to CSGC data. Methods: The SSGC consists of 18,432 CdTe (cadmium telluride) elements, each with a 1.4mm pixel pitch, comprising a 268mm × 134mm effective field of view. A LEHR collimator was used for both SSGC and CSGC planar or SPECT image acquisition. We employed a PRISM 2000XP (Picker, USA) as the CSGC. For first-pass and ECG-gated myocardial imaging, 99mTc-sestamibi 740MBq was injected to a cephalic vein of the dog (Beagle canine). The 30min post injection images in the LAO 45° position were acquired with both gamma cameras under identical conditions (acquisition time, collimator type, and dog body position). The 8-frame and 16-frame ECG-gated myocardial perfusion image data were reconstructed with each scanner specific software. The FWHM of the left ventricular free wall was evaluated by the DRIP (FUJIFILM RI Pharma Co., Ltd., Japan) data analysis software. Results: In the first-pass images, clear, high signal/noise, hemodynamic images (right/left ventricular cavity and aortic arch) generated by the SSGC were observed. The mean FWHM of the left ventricular free wall at 8- and 16-frame 99mTc-sestamibi ECG-gated myocardial perfusion SSGC imaging were measured to be 18.2±1.9mm and 19.4±7.8mm, respectively. In comparison, the CSGC mean FWHM were measured to be 25.9±8.9mm and 25.8±8.6mm, respectively. Thus the SSGC mean FWHM were found to be significantly narrower as compared to the CSGC mean FWHM (p<0.05). Conclusions: The 99mTc-sestamibi myocardial perfusion image obtained by solid-state gamma camera provided higher spatial resolution and enabling more accurate measurement of the ventricular wall as compared to the conventional scintillation gamma camera. This novel solid-state gamma camera should contribute to increasing the number of diagnostic frames and/or the reduction of acquisition time in ECG-gated myocardial perfusion imaging.
- Society of Nuclear Medicine, Inc.