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OtherBASIC SCIENCE INVESTIGATIONS

Epidermal Growth Factor Receptor Inhibition Modulates the Nuclear Localization and Cytotoxicity of the Auger Electron–Emitting Radiopharmaceutical 111In-DTPA–Human Epidermal Growth Factor

Kristy E. Bailey, Danny L. Costantini, Zhongli Cai, Deborah A. Scollard, Zhuo Chen, Raymond M. Reilly and Katherine A. Vallis
Journal of Nuclear Medicine September 2007, 48 (9) 1562-1570; DOI: https://doi.org/10.2967/jnumed.107.044073
Kristy E. Bailey
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Danny L. Costantini
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Zhongli Cai
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Deborah A. Scollard
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Zhuo Chen
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Raymond M. Reilly
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Katherine A. Vallis
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Article Information

vol. 48 no. 9 1562-1570
DOI 
https://doi.org/10.2967/jnumed.107.044073
PubMed 
17704253

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication March 14, 2007
  • Accepted for publication June 14, 2007
  • Published online September 4, 2007.

Article Versions

  • previous version (August 17, 2007 - 08:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2007 by Society of Nuclear Medicine

Author Information

  1. Kristy E. Bailey 1 , 2 ,
  2. Danny L. Costantini 3 , 4 ,
  3. Zhongli Cai 2 ,
  4. Deborah A. Scollard 4 ,
  5. Zhuo Chen 2 ,
  6. Raymond M. Reilly 3 , 4 and
  7. Katherine A. Vallis 1 , 2 , 5
  1. 1Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada; 3Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; 4Division of Nuclear Medicine, Toronto General Hospital Research Institute, Toronto, Ontario, Canada; and 5Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
  1. For correspondence or reprints contact: Katherine A. Vallis, MD, PhD, Radiobiology Research Institute, University of Oxford, Churchill Hospital, Headington, Oxford, U.K. OX3 7LJ. E-mail: katherine.vallis{at}rob.ox.ac.uk
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Journal of Nuclear Medicine: 48 (9)
Journal of Nuclear Medicine
Vol. 48, Issue 9
September 2007
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Epidermal Growth Factor Receptor Inhibition Modulates the Nuclear Localization and Cytotoxicity of the Auger Electron–Emitting Radiopharmaceutical 111In-DTPA–Human Epidermal Growth Factor
Kristy E. Bailey, Danny L. Costantini, Zhongli Cai, Deborah A. Scollard, Zhuo Chen, Raymond M. Reilly, Katherine A. Vallis
Journal of Nuclear Medicine Sep 2007, 48 (9) 1562-1570; DOI: 10.2967/jnumed.107.044073

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Epidermal Growth Factor Receptor Inhibition Modulates the Nuclear Localization and Cytotoxicity of the Auger Electron–Emitting Radiopharmaceutical 111In-DTPA–Human Epidermal Growth Factor
Kristy E. Bailey, Danny L. Costantini, Zhongli Cai, Deborah A. Scollard, Zhuo Chen, Raymond M. Reilly, Katherine A. Vallis
Journal of Nuclear Medicine Sep 2007, 48 (9) 1562-1570; DOI: 10.2967/jnumed.107.044073
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  • RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus
  • Cellular Dosimetry of 111In Using Monte Carlo N-Particle Computer Code: Comparison with Analytic Methods and Correlation with In Vitro Cytotoxicity
  • The Monte Carlo Method in Nuclear Medicine: Current Uses and Future Potential
  • Relationship Between Induction of Phosphorylated H2AX and Survival in Breast Cancer Cells Exposed to 111In-DTPA-hEGF
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