This Month in JNM

Breathing lessons for PET/CT: Bacharach looks at the trade-offs in switching from stand-alone PET to PET/CT and previews 3 articles in this month's JNM that focus on various challenges of CT-based attenuation correction.
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Characterizing pulmonary hypertension: Tunariu and colleagues compare the efficacy of ventilation–perfusion scintigraphy with that of CT pulmonary angiography in identifying patients with chronic thromboembolic pulmonary disease and in hastening the initiation of effective therapies.
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Posthepatectomy liver failure risk: Dinant and colleagues compare the abilities of preoperative hepatobiliary scintigraphy and CT volumetric measurement of future remnant liver to predict postoperative morbidity, organ failure, and mortality in patients undergoing liver resection.
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Tracer influence on lymphoscintigraphy: Bourgeois evaluates whether and how the volume and quantity of injected ^99mTc-labeled colloids––data usually not included in scientific reports––affect lymphoscintigraphic results.
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Cardiac SPECT/CT fusion: Gaemperli and colleagues report on initial experience with fused 3D SPECT/CT in patients with coronary artery disease and on the potential of this technique for providing incremental diagnostic information on the functional relevance of coronary artery lesions.
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PET and MRI in mild dementia: Ishii and colleagues investigate regional and patho physiologic differences in morphologic and functional changes in patients with mild dementia with Lewy bodies and individuals with very early Alzheimer's disease.
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Deep breath-hold PET/CT: Meirelles and colleagues detail the detection and characterization of thoracic lesions by PET/CT imaging acquired with and without a novel deep-inspiration protocol.
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¹⁸F-TYR PET/CT and meningiomas: Rutten and colleagues describe results with PET/CT and 2-¹⁸F-fluoro-l-tyrosine, a marker of amino acid transport, as part of routine yearly follow-up of patients previously irradiated for skull base meningiomas.
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¹⁸F-FLT PET in lymph node staging: Troost and colleagues assess the value of ¹⁸F-FLT PET in determining lymph node status in patients with newly diagnosed squamous cell carcinoma of the head and neck.
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GLP-1 receptors in tumors: Körner and colleagues report on in vitro evaluations of GLP-1 receptor expression in a variety of human tumors and nonneoplastic tissues and discuss the promise of GLP-1 receptors in molecular scintigraphy and targeted radiotherapy.
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PET predictions in NSCLC: Nahmias and colleagues describe patient studies assessing the ability of ¹⁸F-FDG PET to characterize early metabolic response to chemotherapy in patients with non–small cell lung cancer and to predict therapeutic success or failure.
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PET and treatment prognosis: Kim and colleagues evaluate the effectiveness of pretreatment ¹⁸F-FDG PET in providing guidance for choice of initial treatment in patients with squamous cell carcinoma of the oropharynx.
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Postacquisition motion detection in PET: Bundschuh and colleagues report on the feasibility of a technique using list-mode data to detect craniocaudal movement of thoracic and abdominal lesions in PET imaging without an external gating device.
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Delayed PET/CT in bladder cancer: Anjos and colleagues investigate the role of delayed ¹⁸F-FDG PET/CT in the detection and restaging of bladder cancer, using a diuretic and oral hydration to remove excreted tracer from the bladder.
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PET and molecular markers: Riedl and colleagues explore the prognostic capabilities of PET by determining the extent to which presurgical ¹⁸F-FDG PET images in metastatic colorectal cancer correlate with other cellular characteristics and clinical behaviors of these tumors.
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Metabolic asymmetry in epilepsy: Lin and colleagues describe an approach to identify and quantify those aspects of metabolic asymmetry in presurgical PET scans that may accurately predict postsurgical seizure-free clinical outcomes in patients with temporal lobe epilepsy.
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Cardiac PET/CT imaging: Di Carli and colleagues provide an educational overview of the advantages and challenges of myocardial perfusion PET and integrated PET/CT, with a focus on the hybrid technology's potential for translating advances in molecularly targeted imaging to humans.
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Cine CT in cardiac PET/CT: Alessio and colleagues investigate the use of cine CT, acquiring multiple low-dose CT images during a respiratory cycle, as an alternative to helical CT in cardiac PET attenuation correction.
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Iterative partial-volume correction: Teo and colleagues describe an iterative postreconstruction method that corrects for partial-volume errors in PET, thereby enhancing the accuracy of radiopharmaceutical uptake estimates in small tumors.
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CT-corrected canine cardiac PET: Cook and colleagues compare respiration-averaged CT and 4D CT for attenuation correction of cardiac PET in an in vivo canine model.
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Human-derived PET reporter gene: Ponomarev and colleagues describe preliminary assessment of a human-derived intrinsically nonimmunogenic reporter gene for PET imaging of molecular–genetic processes and discuss potential clinical applications.
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¹²⁴I-MIBG hNET reporter gene imaging: Moroz and colleagues detail the construction of a novel internal ribosomal entry site–linked norepinephrine transporter hybrid reporter gene radiolabeled for both nuclear and optical imaging.
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Quantitative PET with microfluidics: Wu and colleagues describe an automated blood sampling device on an integrated microfluidic platform for precise small-quantity blood withdrawal in PET studies of mice.
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ON THE COVER

At top left, perfusion polar maps at stress and rest show a largely reversible anteroapical perfusion defect (arrowhead). At top right, 3-dimensional volume-rendered CT angiogram shows the coronary vessel tree with stenosis of the mid left anterior descending artery (LAD) and proximal stenosis of the first diagonal branch (DA1). At bottom left, fused 3-dimensional SPECT/CT image shows that the DA1 stenosis is the functionally relevant lesion. At bottom right, findings are confirmed by invasive coronary angiography.

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